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Int. J. Mol. Sci. 2016, 17(7), 1118; doi:10.3390/ijms17071118

Cell Fusion in the War on Cancer: A Perspective on the Inception of Malignancy

Departments of Surgery and of Microbiology & Immunology, University of Michigan, A520B Medical Sciences Research Building I, 1150 W. Medical Center Drive, Ann Arbor, MI 48109-5656, USA
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Academic Editor: Thomas Dittmar
Received: 10 May 2016 / Revised: 28 June 2016 / Accepted: 7 July 2016 / Published: 13 July 2016
(This article belongs to the Special Issue Cell Fusion in Cancer)
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Abstract

Cell fusion occurs in development and in physiology and rarely in those settings is it associated with malignancy. However, deliberate fusion of cells and possibly untoward fusion of cells not suitably poised can eventuate in aneuploidy, DNA damage and malignant transformation. How often cell fusion may initiate malignancy is unknown. However, cell fusion could explain the high frequency of cancers in tissues with low underlying rates of cell proliferation and mutation. On the other hand, cell fusion might also engage innate and adaptive immune surveillance, thus helping to eliminate or retard malignancies. Here we consider whether and how cell fusion might weigh on the overall burden of cancer in modern societies. View Full-Text
Keywords: cell fusion; cancer; malignant transformation; aneuploidy; DNA damage; oncogenesis; cancer progression; mitosis; mutation; immune surveillance cell fusion; cancer; malignant transformation; aneuploidy; DNA damage; oncogenesis; cancer progression; mitosis; mutation; immune surveillance
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Platt, J.L.; Zhou, X.; Lefferts, A.R.; Cascalho, M. Cell Fusion in the War on Cancer: A Perspective on the Inception of Malignancy. Int. J. Mol. Sci. 2016, 17, 1118.

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