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Int. J. Mol. Sci. 2016, 17(7), 1064; doi:10.3390/ijms17071064

Intra-Articular Injections of Platelet-Rich Plasma versus Hyaluronic Acid in the Treatment of Osteoarthritic Knee Pain: A Randomized Clinical Trial in the Context of the Spanish National Health Care System

Department of Orthopedic Surgery and Traumatology, Virgen de la Victoria University Hospital, Málaga E-29010, Spain
Department of Anestesiology. Pain’s Treatment Unit. Virgen de la Victoria University Hospital, MálagaE-29010, Spain
Málaga Tissue Bank, Regional Blood Center, Málaga E-29009, Spain
Department of Health Sciences, University of Jaén, Jaén E-23071, Spain
Biopathology and Regenerative Medicine Institute (IBIMER), Centre for Biomedical Research, University of Granada, Granada E-18071, Spain
Department of Human Anatomy and Embryology, Faculty of Medicine, University of Granada, Granada E-18016, Spain
Biosanitary Institute of Granada (ibs. GRANADA), University Hospitals of Granada-University of Granada, Granada, Granada E-18016, Spain
Author to whom correspondence should be addressed.
Academic Editor: Ge Zhang
Received: 18 April 2016 / Revised: 23 June 2016 / Accepted: 23 June 2016 / Published: 2 July 2016
(This article belongs to the Special Issue Translational Molecular Medicine & Molecular Drug Discovery)
View Full-Text   |   Download PDF [385 KB, uploaded 2 July 2016]   |  


Intra-articular injection of platelet-rich plasma (PRP) has been established as a suitable treatment for knee osteoarthritis. Here, we present a double-blind randomized controlled clinical trial, conducted in a public Hospital of the Spanish National Health Care System, to evaluate the efficacy of injecting autologous PRP versus hyaluronic acid (HA) in knee osteoarthritis. PRP was manufactured in Malaga’s Regional Blood Center (Spain). Patients that met the eligibility criteria were randomized into a PRP group or a HA group. Pain and functional improvements were assessed pre- and post-treatment (three and six months follow-up) using the Visual Analogue Scale (VAS); the Knee and Osteoarthritis Outcome System (KOOS) scale and the European Quality of Life scale (EUROQOL). Both groups presented pain reduction at six months. The VAS scores for the PRP group improved by at least 50% from their initial value, particularly at three months following the final infiltration, with results resembling those of the HA group at six months. PRP was more effective in patients with lower osteoarthritis grades. Both treatments improved pain in knee osteoarthritis patients without statistically significant differences between them. However, PRP injection was proved to improve pain three months after the final infiltration and to be more effective in lower osteoarthritis grades. View Full-Text
Keywords: platelet-rich plasma; knee osteoarthritis; clinical trial; hyaluronic acid platelet-rich plasma; knee osteoarthritis; clinical trial; hyaluronic acid

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Montañez-Heredia, E.; Irízar, S.; Huertas, P.J.; Otero, E.; del Valle, M.; Prat, I.; Díaz-Gallardo, M.S.; Perán, M.; Marchal, J.A.; Hernandez-Lamas, M.C. Intra-Articular Injections of Platelet-Rich Plasma versus Hyaluronic Acid in the Treatment of Osteoarthritic Knee Pain: A Randomized Clinical Trial in the Context of the Spanish National Health Care System. Int. J. Mol. Sci. 2016, 17, 1064.

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