Compound K Attenuates the Development of Atherosclerosis in ApoE−/− Mice via LXRα Activation
Abstract
:1. Introduction
2. Results
2.1. Compound K Attenuates Atherosclerotic Lesion and Fatty Liver in ApoE−/− Mice
2.2. Compound K Decreases Serous Inflammatory Cytokines and Modulated Serum Lipid Profiles in ApoE−/− Mice
2.3. Compound K Reduces Inflammasome Activity in Atherosclerotic Lesion
2.4. Compound K Promotes the Expression of Reverse Cholesterol Transport (RCT) Related Proteins
2.5. Compound K Inhibits the Formation of Foam Cell and the Activity of Inflammasome in Macrophages
3. Discussion
4. Materials and Methods
4.1. Mice and Treatments
4.2. Histology and Image Analysis
4.3. Determination of Serous Lipid and Cytokines
4.4. Cell Culture and Treatments
4.5. Immunoblotting
4.6. Analysis of Cholesterol Ester Content of Aorta and Foam Cells
4.7. Statistical Analysis
Supplementary Materials
Acknowledgments
Author Contributions
Conflicts of Interest
Abbreviations
ABC | ATP-binding cassette transporter |
GGPP | Geranylgeranyl pyrophosphate |
HDL | high density lipoprotein |
IL | interleukin |
LDL | low density lipoprotein |
LXRα | liver X receptor α |
NF-κB | nuclear factor kappa B |
NLRP3 | NOD-like receptor protein-3 |
RCT | reverse cholesterol transport |
SREBP | sterol regulatory element-binding protein |
VLDL | very low density lipoprotein |
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Zhou, L.; Zheng, Y.; Li, Z.; Bao, L.; Dou, Y.; Tang, Y.; Zhang, J.; Zhou, J.; Liu, Y.; Jia, Y.; et al. Compound K Attenuates the Development of Atherosclerosis in ApoE−/− Mice via LXRα Activation. Int. J. Mol. Sci. 2016, 17, 1054. https://doi.org/10.3390/ijms17071054
Zhou L, Zheng Y, Li Z, Bao L, Dou Y, Tang Y, Zhang J, Zhou J, Liu Y, Jia Y, et al. Compound K Attenuates the Development of Atherosclerosis in ApoE−/− Mice via LXRα Activation. International Journal of Molecular Sciences. 2016; 17(7):1054. https://doi.org/10.3390/ijms17071054
Chicago/Turabian StyleZhou, Li, Yu Zheng, Zhuoying Li, Lingxia Bao, Yin Dou, Yuan Tang, Jianxiang Zhang, Jianzhi Zhou, Ya Liu, Yi Jia, and et al. 2016. "Compound K Attenuates the Development of Atherosclerosis in ApoE−/− Mice via LXRα Activation" International Journal of Molecular Sciences 17, no. 7: 1054. https://doi.org/10.3390/ijms17071054