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Int. J. Mol. Sci. 2016, 17(7), 1040; doi:10.3390/ijms17071040

Cell Models and Their Application for Studying Adipogenic Differentiation in Relation to Obesity: A Review

1
Department of Biochemistry and Molecular Biology II, School of Pharmacy, Campus de Cartuja s/n, 18071, Institute of Nutrition and Food Technology “José Mataix”, Center of Biomedical Research, Avenida del Conocimiento s/n, 18016, University of Granada, Granada 18071, Spain
2
Instituto de Investigación Biosanitaria ibs, Complejo Hospitalario Universitario de Granada/Universidad de Granada, Granada 18014, Spain
3
CIBEROBN (Physiopathology of Obesity and Nutrition CB12/03/30038), Instituto de Salud Carlos III (ISCIII), Madrid 28029, Spain
*
Author to whom correspondence should be addressed.
Academic Editor: Toshiro Arai
Received: 24 May 2016 / Revised: 23 June 2016 / Accepted: 24 June 2016 / Published: 30 June 2016
(This article belongs to the Special Issue Molecular Research on Obesity and Diabetes)
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Abstract

Over the last several years, the increasing prevalence of obesity has favored an intense study of adipose tissue biology and the precise mechanisms involved in adipocyte differentiation and adipogenesis. Adipocyte commitment and differentiation are complex processes, which can be investigated thanks to the development of diverse in vitro cell models and molecular biology techniques that allow for a better understanding of adipogenesis and adipocyte dysfunction associated with obesity. The aim of the present work was to update the different animal and human cell culture models available for studying the in vitro adipogenic differentiation process related to obesity and its co-morbidities. The main characteristics, new protocols, and applications of the cell models used to study the adipogenesis in the last five years have been extensively revised. Moreover, we depict co-cultures and three-dimensional cultures, given their utility to understand the connections between adipocytes and their surrounding cells in adipose tissue. View Full-Text
Keywords: adipocytes; beige cells; brown adipose tissue; cell culture techniques; cell differentiation; in vitro techniques; obesity; white adipose tissue adipocytes; beige cells; brown adipose tissue; cell culture techniques; cell differentiation; in vitro techniques; obesity; white adipose tissue
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Ruiz-Ojeda, F.J.; Rupérez, A.I.; Gomez-Llorente, C.; Gil, A.; Aguilera, C.M. Cell Models and Their Application for Studying Adipogenic Differentiation in Relation to Obesity: A Review. Int. J. Mol. Sci. 2016, 17, 1040.

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