Modulation of PPAR Expression and Activity in Response to Polyphenolic Compounds in High Fat Diets
AbstractPeroxisome proliferator-activated receptors (PPAR) are transcription factors that modulate energy metabolism in liver, adipose tissue and muscle. High fat diets (HFD) can negatively impact PPAR expression or activity, favoring obesity, dyslipidemia, insulin resistance and other conditions. However, polyphenols (PP) found in vegetable foodstuffs are capable of positively modulating this pathway. We therefore focused this review on the possible effects that PP can have on PPAR when administered together with HFD. We found that PP from diverse sources, such as coffee, olives, rice, berries and others, are capable of inducing the expression of genes involved in a decrease of adipose mass, liver and serum lipids and lipid biosynthesis in animal and cell models of HFD. Since cells or gut bacteria can transform PP into different metabolites, it is possible that a synergistic or antagonistic effect ultimately occurs. PP molecules from vegetable sources are an interesting option to maintain or return to a state of energy homeostasis, possibly due to an adequate PPAR expression and activity. View Full-Text
Share & Cite This Article
Domínguez-Avila, J.A.; González-Aguilar, G.A.; Alvarez-Parrilla, E.; de la Rosa, L.A. Modulation of PPAR Expression and Activity in Response to Polyphenolic Compounds in High Fat Diets. Int. J. Mol. Sci. 2016, 17, 1002.
Domínguez-Avila JA, González-Aguilar GA, Alvarez-Parrilla E, de la Rosa LA. Modulation of PPAR Expression and Activity in Response to Polyphenolic Compounds in High Fat Diets. International Journal of Molecular Sciences. 2016; 17(7):1002.Chicago/Turabian Style
Domínguez-Avila, J. A.; González-Aguilar, Gustavo A.; Alvarez-Parrilla, Emilio; de la Rosa, Laura A. 2016. "Modulation of PPAR Expression and Activity in Response to Polyphenolic Compounds in High Fat Diets." Int. J. Mol. Sci. 17, no. 7: 1002.
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.