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Int. J. Mol. Sci. 2016, 17(7), 1002; doi:10.3390/ijms17071002

Modulation of PPAR Expression and Activity in Response to Polyphenolic Compounds in High Fat Diets

1
Coordinación de Tecnología de Alimentos de Origen Vegetal, Centro de Investigación en Alimentación y Desarrollo A. C., Carretera a La Victoria km 0.6, AP 1735, CP 83304 Hermosillo, Sonora, Mexico
2
Departamento de Ciencias Químico-Biológicas, Instituto de Ciencias Biomédicas, Universidad Autónoma de Ciudad Juárez, Anillo Envolvente del PRONAF y Estocolmo s/n, CP 32310 Ciudad Juárez, Chihuahua, Mexico
*
Author to whom correspondence should be addressed.
Academic Editor: Béatrice Desvergne
Received: 11 May 2016 / Revised: 14 June 2016 / Accepted: 20 June 2016 / Published: 29 June 2016
View Full-Text   |   Download PDF [264 KB, uploaded 29 June 2016]

Abstract

Peroxisome proliferator-activated receptors (PPAR) are transcription factors that modulate energy metabolism in liver, adipose tissue and muscle. High fat diets (HFD) can negatively impact PPAR expression or activity, favoring obesity, dyslipidemia, insulin resistance and other conditions. However, polyphenols (PP) found in vegetable foodstuffs are capable of positively modulating this pathway. We therefore focused this review on the possible effects that PP can have on PPAR when administered together with HFD. We found that PP from diverse sources, such as coffee, olives, rice, berries and others, are capable of inducing the expression of genes involved in a decrease of adipose mass, liver and serum lipids and lipid biosynthesis in animal and cell models of HFD. Since cells or gut bacteria can transform PP into different metabolites, it is possible that a synergistic or antagonistic effect ultimately occurs. PP molecules from vegetable sources are an interesting option to maintain or return to a state of energy homeostasis, possibly due to an adequate PPAR expression and activity. View Full-Text
Keywords: PPAR; polyphenols; high fat; gene expression PPAR; polyphenols; high fat; gene expression
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Domínguez-Avila, J.A.; González-Aguilar, G.A.; Alvarez-Parrilla, E.; de la Rosa, L.A. Modulation of PPAR Expression and Activity in Response to Polyphenolic Compounds in High Fat Diets. Int. J. Mol. Sci. 2016, 17, 1002.

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