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Int. J. Mol. Sci. 2016, 17(6), 991; doi:10.3390/ijms17060991

Serum Levels of Substance P and Mortality in Patients with a Severe Acute Ischemic Stroke

1
Intensive Care Unit, Hospital Universitario de Canarias, Ofra, s/n. La Laguna, Tenerife 38320, Spain
2
Intensive Care Unit, Hospital Universitario Nuestra Señora Candelaria, Crta Rosario s/n, Santa Cruz Tenerife 38010, Spain
3
Unidad de Genética, Instituto de Enfermedades Tropicales y Salud Pública de Canarias, Universidad de La Laguna, Campus de Anchieta, Avda. Astrofísico Francisco Sánchez s/n, La Laguna, Tenerife 38071, Spain
4
Laboratory Department, Hospital Universitario de Canarias, Ofra, s/n. La Laguna, Tenerife 38320, Spain
5
Intensive Care Unit, Hospital General La Palma, Buenavista de Arriba s/n, Breña Alta, La Palma 38713, Spain
6
Intensive Care Unit, Hospital Clínico Universitario de Valencia, Avda. Blasco Ibáñez nº17–19, Valencia 46004, Spain
7
Servicio de Bioquímica Clínica, Complejo Hospitalario Universitario Insular Materno-Infantil, Plaza Dr. Pasteur s/n, Las Palmas de Gran Canaria 35016, Spain
8
Intensive Care Unit, Hospital Universitario Dr. Negrín, CIBERES. Barranco de la Ballena s/n, Las Palmas de Gran Canaria 35010, Spain
*
Author to whom correspondence should be addressed.
Academic Editor: Xiaofeng Jia
Received: 12 May 2016 / Revised: 7 June 2016 / Accepted: 15 June 2016 / Published: 22 June 2016
(This article belongs to the Special Issue Neurological Injuries’ Monitoring, Tracking and Treatment 2016)
View Full-Text   |   Download PDF [742 KB, uploaded 22 June 2016]   |  

Abstract

Substance P (SP), a member of tachykinin family, is involved in the inflammation of the central nervous system and in the appearance of cerebral edema. Higher serum levels of SP have been found in 18 patients with cerebral ischemia compared with healthy controls. The aim of our multi-center study was to analyze the possible association between serum levels of SP and mortality in ischemic stroke patients. We included patients with malignant middle cerebral artery infarction (MMCAI) and a Glasgow Coma Scale (GCS) lower than 9. Non-surviving patients at 30 days (n = 31) had higher serum concentrations of SP levels at diagnosis of severe MMCAI than survivors (n = 30) (p < 0.001). We found in multiple regression an association between serum concentrations of SP higher than 362 pg/mL and mortality at 30 days (Odds Ratio = 5.33; 95% confidence interval = 1.541–18.470; p = 0.008) after controlling for age and GCS. Thus, the major novel finding of our study was the association between serum levels of SP and mortality in patients suffering from severe acute ischemic stroke. View Full-Text
Keywords: substance P; stroke; mortality; cerebral infarction substance P; stroke; mortality; cerebral infarction
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MDPI and ACS Style

Lorente, L.; Martín, M.M.; Almeida, T.; Pérez-Cejas, A.; Ramos, L.; Argueso, M.; Riaño-Ruiz, M.; Solé-Violán, J.; Hernández, M. Serum Levels of Substance P and Mortality in Patients with a Severe Acute Ischemic Stroke. Int. J. Mol. Sci. 2016, 17, 991.

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