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Int. J. Mol. Sci. 2016, 17(6), 989; doi:10.3390/ijms17060989

The Obesity-Breast Cancer Conundrum: An Analysis of the Issues

Cancer Prevention Laboratory, Colorado State University, Fort Collins, CO 80523, USA
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Author to whom correspondence should be addressed.
Academic Editor: Dario Marchetti
Received: 22 May 2016 / Revised: 9 June 2016 / Accepted: 15 June 2016 / Published: 22 June 2016
(This article belongs to the Special Issue Advances in Nutritional Epidemiology)
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Abstract

Breast cancer develops over a timeframe of 2–3 decades prior to clinical detection. Given this prolonged latency, it is somewhat unexpected from a biological perspective that obesity has no effect or reduces the risk for breast cancer in premenopausal women yet increases the risk for breast cancer in postmenopausal women. This conundrum is particularly striking in light of the generally negative effects of obesity on breast cancer outcomes, including larger tumor size at diagnosis and poorer prognosis in both pre- and postmenopausal women. This review and analysis identifies factors that may contribute to this apparent conundrum, issues that merit further investigation, and characteristics of preclinical models for breast cancer and obesity that should be considered if animal models are used to deconstruct the conundrum. View Full-Text
Keywords: breast cancer; obesity; mechanisms; preclinical models breast cancer; obesity; mechanisms; preclinical models
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Matthews, S.B.; Thompson, H.J. The Obesity-Breast Cancer Conundrum: An Analysis of the Issues. Int. J. Mol. Sci. 2016, 17, 989.

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