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Int. J. Mol. Sci. 2016, 17(6), 972; doi:10.3390/ijms17060972

Role of Receptor Tyrosine Kinase Signaling in Renal Fibrosis

1
Department of Nephrology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200120, China
2
Department of Medicine, Rhode Island Hospital, Alpert Medical School of Brown University, Providence, RI 02903, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Alan Parrish
Received: 5 April 2016 / Revised: 23 May 2016 / Accepted: 1 June 2016 / Published: 20 June 2016
(This article belongs to the Special Issue Advances in Chronic Kidney Disease)
View Full-Text   |   Download PDF [571 KB, uploaded 20 June 2016]   |  

Abstract

Renal fibrosis can be induced in different renal diseases, but ultimately progresses to end stage renal disease. Although the pathophysiologic process of renal fibrosis have not been fully elucidated, it is characterized by glomerulosclerosis and/or tubular interstitial fibrosis, and is believed to be caused by the proliferation of renal inherent cells, including glomerular epithelial cells, mesangial cells, and endothelial cells, along with defective kidney repair, renal interstitial fibroblasts activation, and extracellular matrix deposition. Receptor tyrosine kinases (RTKs) regulate a variety of cell physiological processes, including metabolism, growth, differentiation, and survival. Many studies from in vitro and animal models have provided evidence that RTKs play important roles in the pathogenic process of renal fibrosis. It is also showed that tyrosine kinases inhibitors (TKIs) have anti-fibrotic effects in basic research and clinical trials. In this review, we summarize the evidence for involvement of specific RTKs in renal fibrosis process and the employment of TKIs as a therapeutic approach for renal fibrosis. View Full-Text
Keywords: receptor tyrosine kinases; platelet-derived growth factors receptor; fibroblast growth factor receptor; vascular endothelial growth factors receptor; epidermal growth factor receptor; insulin-like growth factor receptor; discoidin domain receptors; growth arrest-specific gene; tyrosine kinase inhibitors; renal fibrosis receptor tyrosine kinases; platelet-derived growth factors receptor; fibroblast growth factor receptor; vascular endothelial growth factors receptor; epidermal growth factor receptor; insulin-like growth factor receptor; discoidin domain receptors; growth arrest-specific gene; tyrosine kinase inhibitors; renal fibrosis
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Liu, F.; Zhuang, S. Role of Receptor Tyrosine Kinase Signaling in Renal Fibrosis. Int. J. Mol. Sci. 2016, 17, 972.

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