Role of Receptor Tyrosine Kinase Signaling in Renal Fibrosis
AbstractRenal fibrosis can be induced in different renal diseases, but ultimately progresses to end stage renal disease. Although the pathophysiologic process of renal fibrosis have not been fully elucidated, it is characterized by glomerulosclerosis and/or tubular interstitial fibrosis, and is believed to be caused by the proliferation of renal inherent cells, including glomerular epithelial cells, mesangial cells, and endothelial cells, along with defective kidney repair, renal interstitial fibroblasts activation, and extracellular matrix deposition. Receptor tyrosine kinases (RTKs) regulate a variety of cell physiological processes, including metabolism, growth, differentiation, and survival. Many studies from in vitro and animal models have provided evidence that RTKs play important roles in the pathogenic process of renal fibrosis. It is also showed that tyrosine kinases inhibitors (TKIs) have anti-fibrotic effects in basic research and clinical trials. In this review, we summarize the evidence for involvement of specific RTKs in renal fibrosis process and the employment of TKIs as a therapeutic approach for renal fibrosis. View Full-Text
Scifeed alert for new publicationsNever miss any articles matching your research from any publisher
- Get alerts for new papers matching your research
- Find out the new papers from selected authors
- Updated daily for 49'000+ journals and 6000+ publishers
- Define your Scifeed now
Liu, F.; Zhuang, S. Role of Receptor Tyrosine Kinase Signaling in Renal Fibrosis. Int. J. Mol. Sci. 2016, 17, 972.
Liu F, Zhuang S. Role of Receptor Tyrosine Kinase Signaling in Renal Fibrosis. International Journal of Molecular Sciences. 2016; 17(6):972.Chicago/Turabian Style
Liu, Feng; Zhuang, Shougang. 2016. "Role of Receptor Tyrosine Kinase Signaling in Renal Fibrosis." Int. J. Mol. Sci. 17, no. 6: 972.
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.