Next Article in Journal
Comprehensive and Quantitative Proteomic Analysis of Metamorphosis-Related Proteins in the Veined Rapa Whelk, Rapana venosa
Next Article in Special Issue
Potential Diagnostic, Prognostic and Therapeutic Targets of MicroRNAs in Human Gastric Cancer
Previous Article in Journal
Immune Mechanisms in Myelodysplastic Syndrome
Previous Article in Special Issue
Spatial Partitioning of miRNAs Is Related to Sequence Similarity in Overall Transcriptome
Article Menu
Issue 6 (June) cover image

Export Article

Open AccessReview
Int. J. Mol. Sci. 2016, 17(6), 909; doi:10.3390/ijms17060909

The Role of miRNA in Papillary Thyroid Cancer in the Context of miRNA Let-7 Family

1
Department of Experimental Physiology, Chair of Experimental and Clinical Physiology, Medical University of Lodz, Lodz 92-215, Poland
2
Department of Clinical Physiology, Medical University of Lodz, Lodz 92-215, Poland
*
Author to whom correspondence should be addressed.
Academic Editor: Y-h. Taguchi
Received: 14 April 2016 / Revised: 22 May 2016 / Accepted: 3 June 2016 / Published: 15 June 2016
(This article belongs to the Special Issue MicroRNA Regulation)
View Full-Text   |   Download PDF [408 KB, uploaded 15 June 2016]   |  

Abstract

Papillary thyroid carcinoma (PTC) is the most common endocrine malignancy. RET/PTC rearrangement is the most common genetic modification identified in this category of cancer, increasing proliferation and dedifferentiation by the activation of the RET/PTC-RAS-BRAF-MAPK-ERK signaling pathway. Recently, let-7 miRNA was found to reduce RAS levels, acting as a tumor suppressor gene. Circulating miRNA profiles of the let-7 family may be used as novel noninvasive diagnostic, prognostic, treatment and surveillance markers for PTC. View Full-Text
Keywords: miRNAs; let-7 family; papillary thyroid cancer; carcinogenesis miRNAs; let-7 family; papillary thyroid cancer; carcinogenesis
Figures

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Perdas, E.; Stawski, R.; Nowak, D.; Zubrzycka, M. The Role of miRNA in Papillary Thyroid Cancer in the Context of miRNA Let-7 Family. Int. J. Mol. Sci. 2016, 17, 909.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top