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Int. J. Mol. Sci. 2016, 17(6), 779; doi:10.3390/ijms17060779

Recent Advances in Developing Small Molecules Targeting Nucleic Acid

1,2,3
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1,2,3
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1,2,3,* and 1,2,3,*
1
Institute of Integrated Bioinfomedicine and Translational Science (IBTS), School of Chinese Medicine, Hong Kong Baptist University, Hong Kong 999077, China
2
Shenzhen Lab of Combinatorial Compounds and Targeted Drug Delivery, HKBU Institute of Research and Continuing Education, Shenzhen 518000, China
3
Institute for Advancing Translational Medicine in Bone and Joint Diseases, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong 999077, China
*
Authors to whom correspondence should be addressed.
Academic Editor: Mateus Webba da Silva
Received: 2 March 2016 / Revised: 1 May 2016 / Accepted: 9 May 2016 / Published: 30 May 2016

Abstract

Nucleic acids participate in a large number of biological processes. However, current approaches for small molecules targeting protein are incompatible with nucleic acids. On the other hand, the lack of crystallization of nucleic acid is the limiting factor for nucleic acid drug design. Because of the improvements in crystallization in recent years, a great many structures of nucleic acids have been reported, providing basic information for nucleic acid drug discovery. This review focuses on the discovery and development of small molecules targeting nucleic acids. View Full-Text
Keywords: nucleic acids; nucleic acids targeting; small molecules; DNA drug discovery; RNA drug discovery nucleic acids; nucleic acids targeting; small molecules; DNA drug discovery; RNA drug discovery
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Wang, M.; Yu, Y.; Liang, C.; Lu, A.; Zhang, G. Recent Advances in Developing Small Molecules Targeting Nucleic Acid. Int. J. Mol. Sci. 2016, 17, 779.

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