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Int. J. Mol. Sci. 2016, 17(5), 701; doi:10.3390/ijms17050701

Design and Application of Antimicrobial Peptide Conjugates

Department of Chemistry, Institute of Biochemistry, University of Cologne, Zuelpicher Str. 47, D-50674 Cologne, Germany
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Author to whom correspondence should be addressed.
Academic Editor: Már Másson
Received: 15 March 2016 / Revised: 25 April 2016 / Accepted: 4 May 2016 / Published: 11 May 2016
(This article belongs to the Special Issue Drug Delivery and Antimicrobial Agents)
View Full-Text   |   Download PDF [268 KB, uploaded 11 May 2016]

Abstract

Antimicrobial peptides (AMPs) are an interesting class of antibiotics characterized by their unique antibiotic activity and lower propensity for developing resistance compared to common antibiotics. They belong to the class of membrane-active peptides and usually act selectively against bacteria, fungi and protozoans. AMPs, but also peptide conjugates containing AMPs, have come more and more into the focus of research during the last few years. Within this article, recent work on AMP conjugates is reviewed. Different aspects will be highlighted as a combination of AMPs with antibiotics or organometallic compounds aiming to increase antibacterial activity or target selectivity, conjugation with photosensitizers for improving photodynamic therapy (PDT) or the attachment to particles, to name only a few. Owing to the enormous resonance of antimicrobial conjugates in the literature so far, this research topic seems to be very attractive to different scientific fields, like medicine, biology, biochemistry or chemistry. View Full-Text
Keywords: antimicrobial peptides; antimicrobial peptide conjugates; antibiotics; photosensitizer; nanoparticles; organometallic complexes antimicrobial peptides; antimicrobial peptide conjugates; antibiotics; photosensitizer; nanoparticles; organometallic complexes
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Reinhardt, A.; Neundorf, I. Design and Application of Antimicrobial Peptide Conjugates. Int. J. Mol. Sci. 2016, 17, 701.

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