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Int. J. Mol. Sci. 2016, 17(4), 527; doi:10.3390/ijms17040527

Bavachin from Psoralea corylifolia Improves Insulin-Dependent Glucose Uptake through Insulin Signaling and AMPK Activation in 3T3-L1 Adipocytes

1
College of Pharmacy and Research Center for Cell Fate Control, Sookmyung Women’s University, 52 Hyochangwongil, Yongsan-gu, Seoul 140-742, Korea
2
Natural Products Research Institute, College of Pharmacy, Seoul National University, 1 Gwanak-ro, Gwanak-Gu, Seoul 151-742, Korea
*
Author to whom correspondence should be addressed.
Academic Editor: Maurizio Battino
Received: 29 February 2016 / Revised: 31 March 2016 / Accepted: 1 April 2016 / Published: 8 April 2016
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Abstract

The fruit of Psoralea corylifolia L. (Fabaceae) (PC), known as “Bo-Gol-Zhee” in Korea has been used as traditional medicine. Ethanol and aqueous extracts of PC have an anti-hyperglycemic effect by increasing plasma insulin levels and decreasing blood glucose and total plasma cholesterol levels in type 2 diabetic rats. In this study, we purified six compounds from PC and investigated their anti-diabetic effect. Among the purified compounds, bavachin most potently accumulated lipids during adipocyte differentiation. Intracellular lipid accumulation was measured by Oil Red-O (ORO) cell staining to investigate the effect of compounds on adipogenesis. Consistently, bavachin activated gene expression of adipogenic transcriptional factors, proliferator-activated receptorγ (PPARγ) and CCAAT/enhancer binding protein-α (C/EBPα). Bavachin also increased adiponectin expression and secretion in adipocytes. Moreover, bavachin increased insulin-induced glucose uptake by differentiated adipocytes and myoblasts. In differentiated adipocytes, we found that bavachin enhanced glucose uptake via glucose transporter 4 (GLUT4) translocation by activating the Akt and 5′AMP-activated protein kinase (AMPK) pathway in the presence or absence of insulin. These results suggest that bavachin from Psoralea corylifolia might have therapeutic potential for type 2 diabetes by activating insulin signaling pathways. View Full-Text
Keywords: diabetes mellitus; glucose uptake; Psoralea corylifolia; 3T3-L1; adipogenesis diabetes mellitus; glucose uptake; Psoralea corylifolia; 3T3-L1; adipogenesis
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Lee, H.; Li, H.; Noh, M.; Ryu, J.-H. Bavachin from Psoralea corylifolia Improves Insulin-Dependent Glucose Uptake through Insulin Signaling and AMPK Activation in 3T3-L1 Adipocytes. Int. J. Mol. Sci. 2016, 17, 527.

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