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Int. J. Mol. Sci. 2016, 17(4), 460; doi:10.3390/ijms17040460

NAFLD and Increased Aortic Stiffness: Parallel or Common Physiopathological Mechanisms?

Department of Internal Medicine, Medical School and University Hospital Clementino Fraga Filho, Universidade Federal do Rio de Janeiro, Rua Croton 72, Rio de Janeiro 22750-240, Brazil
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Academic Editor: Giovanni Targher
Received: 18 February 2016 / Revised: 8 March 2016 / Accepted: 21 March 2016 / Published: 20 April 2016
(This article belongs to the Special Issue Non-Alcoholic Fatty Liver Disease Research 2016)
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Abstract

Non-alcoholic fatty liver disease (NAFLD) has become the leading cause of chronic liver diseases worldwide. Liver inflammation and fibrosis related to NAFLD contribute to disease progression and increasing liver-related mortality and morbidity. Increasing data suggest that NAFLD may be linked to atherosclerotic vascular disease independent of other established cardiovascular risk factors. Central arterial stiffness has been recognized as a measure of cumulative cardiovascular risk marker load, and the measure of carotid-femoral pulse wave velocity (cf-PWV) is regarded as the gold standard assessment of aortic stiffness. It has been shown that increased aortic stiffness predicts cardiovascular morbidity and mortality in several clinical settings, including type 2 diabetes mellitus, a well-known condition associated with advanced stages of NAFLD. Furthermore, recently-published studies reported a strong association between NAFLD and increased arterial stiffness, suggesting a possible link in the pathogenesis of atherosclerosis and NAFLD. We sought to review the published data on the associations between NAFLD and aortic stiffness, in order to better understand the interplay between these two conditions and identify possible common physiopathological mechanisms. View Full-Text
Keywords: non-alcoholic fatty liver disease; steatohepatitis; liver fibrosis; arterial stiffness; pulse wave velocity non-alcoholic fatty liver disease; steatohepatitis; liver fibrosis; arterial stiffness; pulse wave velocity
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Villela-Nogueira, C.A.; Leite, N.C.; Cardoso, C.R.L.; Salles, G.F. NAFLD and Increased Aortic Stiffness: Parallel or Common Physiopathological Mechanisms? Int. J. Mol. Sci. 2016, 17, 460.

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