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Int. J. Mol. Sci. 2016, 17(4), 562; doi:10.3390/ijms17040562

NAFLD and Chronic Kidney Disease

1
Division of Renal Diseases and Hypertension, University of Colorado Hospital, Aurora, CO 80045, USA
2
Division of Renal Diseases and Hypertension, University of Colorado Denver, 13199 East Montview Boulevard, Suite 495, Aurora, CO 80045, USA
*
Authors to whom correspondence should be addressed.
Academic Editors: Amedeo Lonardo and Giovanni Targher
Received: 1 March 2016 / Revised: 25 March 2016 / Accepted: 28 March 2016 / Published: 14 April 2016
(This article belongs to the Special Issue Non-Alcoholic Fatty Liver Disease Research 2016)
View Full-Text   |   Download PDF [510 KB, uploaded 14 April 2016]   |  

Abstract

Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease in developed countries and it is now considered a risk factor for cardiovascular disease. Evidence linking NAFLD to the development and progression of chronic kidney disease (CKD) is emerging as a popular area of scientific interest. The rise in simultaneous liver-kidney transplantation as well as the significant cost associated with the presence of chronic kidney disease in the NAFLD population make this entity a worthwhile target for screening and therapeutic intervention. While several cross-sectional and case control studies have been published to substantiate these theories, very little data exists on the underlying cause of NAFLD and CKD. In this review, we will discuss the most recent publications on the diagnosis of NAFLD as well new evidence regarding the pathophysiology of NAFLD and CKD as an inflammatory disorder. These mechanisms include the role of obesity, the renin-angiotensin system, and dysregulation of fructose metabolism and lipogenesis in the development of both disorders. Further investigation of these pathways may lead to novel therapies that aim to target the NAFLD and CKD. However, more prospective studies that include information on both renal and liver histology will be necessary in order to understand the relationship between these diseases. View Full-Text
Keywords: non-alcoholic fatty liver disease; chronic kidney disease; non-alcoholic steatohepatitis; inflammation; review non-alcoholic fatty liver disease; chronic kidney disease; non-alcoholic steatohepatitis; inflammation; review
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Marcuccilli, M.; Chonchol, M. NAFLD and Chronic Kidney Disease. Int. J. Mol. Sci. 2016, 17, 562.

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