Next Article in Journal
Microarray Study of Pathway Analysis Expression Profile Associated with MicroRNA-29a with Regard to Murine Cholestatic Liver Injuries
Next Article in Special Issue
Biomaterials with Antibacterial and Osteoinductive Properties to Repair Infected Bone Defects
Previous Article in Journal
Dietary Apigenin Exerts Immune-Regulatory Activity in Vivo by Reducing NF-κB Activity, Halting Leukocyte Infiltration and Restoring Normal Metabolic Function
Previous Article in Special Issue
Two Different Approaches for Oral Administration of Voriconazole Loaded Formulations: Electrospun Fibers versus β-Cyclodextrin Complexes
Article Menu
Issue 3 (March) cover image

Export Article

Open AccessArticle
Int. J. Mol. Sci. 2016, 17(3), 316; doi:10.3390/ijms17030316

Laminin Receptor-Avid Nanotherapeutic EGCg-AuNPs as a Potential Alternative Therapeutic Approach to Prevent Restenosis

1,2
,
1,2
,
3
,
3,4,†,* and 1,2,4,5,6,7,†,*
1
Department of Radiology, University of Missouri, Columbia, MO 65211, USA
2
Institute of Green Nanotechnology, University of Missouri, Columbia, MO 65211, USA
3
Department of Medicine, University of Missouri, Harry S. Truman Memorial Veterans Hospital, Columbia, MO 65211, USA
4
Department of Medical Pharmacology and Physiology, University of Missouri, Columbia, MO 65211, USA
5
Department of Physics, University of Missouri, Columbia, MO 65211, USA
6
Department of Biological Engineering, University of Missouri, Columbia, MO 65211, USA
7
University of Missouri Research Reactor, University of Missouri, Columbia, MO 65211, USA
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Academic Editor: Már Másson
Received: 6 November 2015 / Revised: 25 January 2016 / Accepted: 16 February 2016 / Published: 1 March 2016
(This article belongs to the Special Issue Drug Delivery and Antimicrobial Agents)
View Full-Text   |   Download PDF [11765 KB, uploaded 1 March 2016]   |  

Abstract

In our efforts to develop new approaches to treat and prevent human vascular diseases, we report herein our results on the proliferation and migration of human smooth muscles cells (SMCs) and endothelial cells (ECs) using epigallocatechin-3-gallate conjugated gold nanoparticles (EGCg-AuNPs) as possible alternatives to drug coated stents. Detailed in vitro stability studies of EGCg-AuNPs in various biological fluids, affinity and selectivity towards SMCs and ECs have been investigated. The EGCg-AuNPs showed selective inhibitory efficacy toward the migration of SMCs. However, the endothelial cells remained unaffected under similar experimental conditions. The cellular internalization studies have indicated that EGCg-AuNPs internalize into the SMCs and ECs within short periods of time through laminin receptor mediated endocytosis mode. Favorable toxicity profiles and selective affinity toward SMCs and ECs suggest that EGCg-AuNPs may provide attractive alternatives to drug coated stents and therefore offer new therapeutic approaches in treating cardiovascular diseases. View Full-Text
Keywords: epigallocatechin-3-gallate; gold nanoparticles; green synthesis; atherosclerosis epigallocatechin-3-gallate; gold nanoparticles; green synthesis; atherosclerosis
Figures

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Khoobchandani, M.; Katti, K.; Maxwell, A.; Fay, W.P.; Katti, K.V. Laminin Receptor-Avid Nanotherapeutic EGCg-AuNPs as a Potential Alternative Therapeutic Approach to Prevent Restenosis. Int. J. Mol. Sci. 2016, 17, 316.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top