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Int. J. Mol. Sci. 2016, 17(2), 215; doi:10.3390/ijms17020215

G-Protein-Coupled Lysophosphatidic Acid Receptors and Their Regulation of AKT Signaling

1
Institute of Biochemistry and Biotechnology, University of the Punjab, 54590 Lahore, Pakistan
2
Department of Medical Biochemistry and Microbiology, Uppsala University, Biomedical Center, 75123 Uppsala, Sweden
*
Author to whom correspondence should be addressed.
Academic Editors: Kathleen Van Craenenbroeck and Ritva Tikkanen
Received: 19 December 2015 / Revised: 29 January 2016 / Accepted: 1 February 2016 / Published: 5 February 2016
(This article belongs to the Section Biochemistry, Molecular and Cellular Biology)
View Full-Text   |   Download PDF [741 KB, uploaded 5 February 2016]   |  

Abstract

A hallmark of G-protein-coupled receptors (GPCRs) is their ability to recognize and respond to chemically diverse ligands. Lysophospholipids constitute a relatively recent addition to these ligands and carry out their biological functions by activating G-proteins coupled to a large family of cell-surface receptors. This review aims to highlight salient features of cell signaling by one class of these receptors, known as lysophosphatidic acid (LPA) receptors, in the context of phosphatidylinositol 3-kinase (PI3K)–AKT pathway activation. LPA moieties efficiently activate AKT phosphorylation and activation in a multitude of cell types. The interplay between LPA, its receptors, the associated Gαi/o subunits, PI3K and AKT contributes to the regulation of cell survival, migration, proliferation and confers chemotherapy-resistance in certain cancers. However, detailed information on the regulation of PI3K–AKT signals induced by LPA receptors is missing from the literature. Here, some urgent issues for investigation are highlighted. View Full-Text
Keywords: G-protein coupled receptors (GPCR); lysophosphatidic acid (LPA); PI3K; AKT G-protein coupled receptors (GPCR); lysophosphatidic acid (LPA); PI3K; AKT
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Riaz, A.; Huang, Y.; Johansson, S. G-Protein-Coupled Lysophosphatidic Acid Receptors and Their Regulation of AKT Signaling. Int. J. Mol. Sci. 2016, 17, 215.

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