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Int. J. Mol. Sci. 2016, 17(2), 193; doi:10.3390/ijms17020193

The Role of Endoplasmic Reticulum Stress and Unfolded Protein Response in Atherosclerosis

1
Department of Development and Regeneration, KU Leuven, Leuven 3000, Belgium
2
Laboratory of Angiopathology, Institute of General Pathology and Pathophysiology, Russian Academy of Sciences, Moscow 125315, Russia
3
Institute for Atherosclerosis Research, Skolkovo Innovative Center, Moscow 121609, Russia
*
Author to whom correspondence should be addressed.
Academic Editor: Masato Matsuoka
Received: 31 December 2015 / Revised: 31 December 2015 / Accepted: 28 January 2016 / Published: 1 February 2016
(This article belongs to the Special Issue Modulators of Endoplasmic Reticulum Stress)
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Abstract

Pathogenesis of atherosclerosis is a complex process involving several metabolic and signalling pathways. Accumulating evidence demonstrates that endoplasmic reticulum stress and associated apoptosis can be induced in the pathological conditions of atherosclerotic lesions and contribute to the disease progression. Notably, they may play a role in the development of vulnerable plaques that induce thrombosis and are therefore especially dangerous. Endoplasmic reticulum stress response is regulated by several signaling mechanisms that involve protein kinases and transcription factors. Some of these molecules can be regarded as potential therapeutic targets to improve treatment of atherosclerosis. In this review we will discuss the role of endoplasmic reticulum stress and apoptosis in atherosclerosis development in different cell types and summarize the current knowledge on potential therapeutic agents targeting molecules regulating these pathways and their possible use for anti-atherosclerotic therapy. View Full-Text
Keywords: atherosclerosis; endoplasmic reticulum stress; ER stress; atherosclerotic plaque; complicated plaque; ER stress modulators atherosclerosis; endoplasmic reticulum stress; ER stress; atherosclerotic plaque; complicated plaque; ER stress modulators
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Ivanova, E.A.; Orekhov, A.N. The Role of Endoplasmic Reticulum Stress and Unfolded Protein Response in Atherosclerosis. Int. J. Mol. Sci. 2016, 17, 193.

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