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Int. J. Mol. Sci. 2016, 17(2), 179; doi:10.3390/ijms17020179

Plasma Monocyte Chemoattractant Protein-1 Level as a Predictor of the Severity of Community-Acquired Pneumonia

1
Institute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan
2
Division of Pulmonary Medicine, Puli Christian Hospital, Puli Township, Nantou 54546, Taiwan
3
Division of Pulmonary Medicine, Department of Internal Medicine, Wan Fang Hospital, Taipei Medical University, Taipei 116, Taiwan
4
School of Respiratory Therapy, College of Medicine, Taipei Medical University, Taipei 110, Taiwan
5
Graduate Institute of Clinical Medicine, Taipei Medical University, Taipei 110, Taiwan
6
Department of Medical Education and Research, Wan Fang Hospital, Taipei Medical University, Taipei 116, Taiwan
7
Institute of Biochemistry, Microbiology and Immunology, Chung Shan Medical University, Taichung 402, Taiwan
8
Division of Chest, Department of Internal Medicine, Chung Shan Medical University Hospital, Taichung 402, Taiwan
9
Department of Medical Research, Chung Shan Medical University Hospital, Taichung 402, Taiwan
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Academic Editor: William Chi-shing Cho
Received: 8 December 2015 / Revised: 10 January 2016 / Accepted: 26 January 2016 / Published: 29 January 2016
(This article belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
View Full-Text   |   Download PDF [735 KB, uploaded 29 January 2016]   |  

Abstract

Monocyte chemoattractant protein (MCP)-1 increases in the serum of immunocompetent patients with community-acquired pneumonia (CAP). However, the correlation between the circulating level of MCP-1 and severity of CAP remains unclear. This study investigated differential changes in the plasma MCP-1 levels of patients with CAP before and after an antibiotic treatment and further analyzes the association between the CAP severity and MCP-1 levels. We measured the plasma MCP-1 levels of 137 patients with CAP and 74 healthy controls by using a commercial enzyme-linked immunosorbent assay. Upon initial hospitalization, Acute Physiology and Chronic Health Evaluation II (APACHE II); confusion, urea level, respiratory rate, blood pressure, and age of >64 years (CURB-65); and pneumonia severity index (PSI) scores were determined for assessing the CAP severity in these patients. The antibiotic treatment reduced the number of white blood cells (WBCs) and neutrophils as well as the level of C-reactive protein (CRP) and MCP-1. The plasma MCP-1 level, but not the CRP level or WBC count, correlated with the CAP severity according to the PSI (r = 0.509, p < 0.001), CURB-65 (r = 0.468, p < 0.001), and APACHE II (r = 0.360, p < 0.001) scores. We concluded that MCP-1 levels act in the development of CAP and are involved in the severity of CAP. View Full-Text
Keywords: community-acquired pneumonia; pneumonia severity index; monocyte chemoattractant protein-1; biochemical marker community-acquired pneumonia; pneumonia severity index; monocyte chemoattractant protein-1; biochemical marker
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MDPI and ACS Style

Yong, K.-K.; Chang, J.-H.; Chien, M.-H.; Tsao, S.-M.; Yu, M.-C.; Bai, K.-J.; Tsao, T.C.-Y.; Yang, S.-F. Plasma Monocyte Chemoattractant Protein-1 Level as a Predictor of the Severity of Community-Acquired Pneumonia. Int. J. Mol. Sci. 2016, 17, 179.

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