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Int. J. Mol. Sci. 2016, 17(2), 172; doi:10.3390/ijms17020172

Focus on Extracellular Vesicles: Development of Extracellular Vesicle-Based Therapeutic Systems

1
Department of Molecular Pathology, Tokyo Medical University, 6-1-1 Shinjuku, Shinjuku-ku, Tokyo 160-8402, Japan
2
Cellular Stress and Ageing Program, Bionanoscience and Bio-Imaging Program, Bio & Nano-Solutions, D-33647 Bielefeld, Germany
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Received: 22 August 2015 / Accepted: 29 January 2016 / Published: 6 February 2016
(This article belongs to the Special Issue Focus on Extracellular Vesicles)
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Abstract

Many types of cells release phospholipid membrane vesicles thought to play key roles in cell-cell communication, antigen presentation, and the spread of infectious agents. Extracellular vesicles (EVs) carry various proteins, messenger RNAs (mRNAs), and microRNAs (miRNAs), like a “message in a bottle” to cells in remote locations. The encapsulated molecules are protected from multiple types of degradative enzymes in body fluids, making EVs ideal for delivering drugs. This review presents an overview of the potential roles of EVs as natural drugs and novel drug-delivery systems. View Full-Text
Keywords: exosome; microvesicle; extracellular vesicle; exosome; dexosome; outer membrane vesicle; stem cell; drug delivery system; vaccine; clinical trial exosome; microvesicle; extracellular vesicle; exosome; dexosome; outer membrane vesicle; stem cell; drug delivery system; vaccine; clinical trial
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Ohno, S.-I.; Drummen, G.P.C.; Kuroda, M. Focus on Extracellular Vesicles: Development of Extracellular Vesicle-Based Therapeutic Systems. Int. J. Mol. Sci. 2016, 17, 172.

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