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Int. J. Mol. Sci. 2016, 17(12), 2087; doi:10.3390/ijms17122087

MicroRNAs, DNA Damage Response, and Cancer Treatment

Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University, Wuhan 430072, China
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Author to whom correspondence should be addressed.
Academic Editor: William Chi-shing Cho
Received: 6 October 2016 / Revised: 23 November 2016 / Accepted: 7 December 2016 / Published: 12 December 2016
(This article belongs to the Collection Advances in Molecular Oncology)
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Abstract

As a result of various stresses, lesions caused by DNA-damaging agents occur constantly in each cell of the human body. Generally, DNA damage is recognized and repaired by the DNA damage response (DDR) machinery, and the cells survive. When repair fails, the genomic integrity of the cell is disrupted—a hallmark of cancer. In addition, the DDR plays a dual role in cancer development and therapy. Cancer radiotherapy and chemotherapy are designed to eliminate cancer cells by inducing DNA damage, which in turn can promote tumorigenesis. Over the past two decades, an increasing number of microRNAs (miRNAs), small noncoding RNAs, have been identified as participating in the processes regulating tumorigenesis and responses to cancer treatment with radiation therapy or genotoxic chemotherapies, by modulating the DDR. The purpose of this review is to summarize the recent findings on how miRNAs regulate the DDR and discuss the therapeutic functions of miRNAs in cancer in the context of DDR regulation. View Full-Text
Keywords: microRNAs; DNA damage response; DNA repair; radiotherapy; chemotherapy microRNAs; DNA damage response; DNA repair; radiotherapy; chemotherapy
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He, M.; Zhou, W.; Li, C.; Guo, M. MicroRNAs, DNA Damage Response, and Cancer Treatment. Int. J. Mol. Sci. 2016, 17, 2087.

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