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Int. J. Mol. Sci. 2016, 17(12), 2085; doi:10.3390/ijms17122085

Inflammation in Chronic Wounds

1
Sutton Arthritis Research Laboratory, Kolling Institute of Medical Research, University of Sydney, NSW 2065, Australia
2
Murray Maxwell Biomechanics Laboratory, Kolling Institute of Medical Research, University of Sydney, NSW 2065, Australia
*
Author to whom correspondence should be addressed.
Academic Editor: Terrence Piva
Received: 14 October 2016 / Revised: 30 November 2016 / Accepted: 5 December 2016 / Published: 11 December 2016
(This article belongs to the Special Issue Inflammatory Skin Conditions)
View Full-Text   |   Download PDF [629 KB, uploaded 13 December 2016]   |  

Abstract

Non-healing chronic wounds present a major biological, psychological, social, and financial burden on both individual patients and the broader health system. Pathologically extensive inflammation plays a major role in the disruption of the normal healing cascade. The causes of chronic wounds (venous, arterial, pressure, and diabetic ulcers) can be examined through a juxtaposition of normal healing and the rogue inflammatory response created by the common components within chronic wounds (ageing, hypoxia, ischaemia-reperfusion injury, and bacterial colonisation). Wound bed care through debridement, dressings, and antibiotics currently form the basic mode of treatment. Despite recent setbacks, pharmaceutical adjuncts form an interesting area of research. View Full-Text
Keywords: chronic wound; inflammation; venous ulcer; arterial ulcer; pressure ulcer; diabetic ulcer; ageing; hypoxia; ischaemia-reperfusion; bacterial colonisation chronic wound; inflammation; venous ulcer; arterial ulcer; pressure ulcer; diabetic ulcer; ageing; hypoxia; ischaemia-reperfusion; bacterial colonisation
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Zhao, R.; Liang, H.; Clarke, E.; Jackson, C.; Xue, M. Inflammation in Chronic Wounds. Int. J. Mol. Sci. 2016, 17, 2085.

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