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Int. J. Mol. Sci. 2016, 17(12), 2050; doi:10.3390/ijms17122050

Aquaporins in the Spinal Cord

1
Department of Health Science and Technology, Aalborg University, 9220 Aalborg, Denmark
2
Department of Animal Physiology, University of Warmia and Mazury in Olsztyn, 10-752 Olsztyn, Poland
3
Department of Human Physiology, University of Warmia and Mazury in Olsztyn, 10-752 Olsztyn, Poland
4
Department of Biochemistry and Cell Biology, School of Medicine, Kyungpook National University, Taegu 41944, Korea
*
Authors to whom correspondence should be addressed.
Academic Editor: Kenichi Ishibashi
Received: 21 September 2016 / Revised: 16 November 2016 / Accepted: 25 November 2016 / Published: 7 December 2016
(This article belongs to the Special Issue Aquaporin)
View Full-Text   |   Download PDF [13335 KB, uploaded 7 December 2016]   |  

Abstract

Aquaporins (AQPs) are water channel proteins robustly expressed in the central nervous system (CNS). A number of previous studies described the cellular expression sites and investigated their major roles and function in the brain and spinal cord. Among thirteen different mammalian AQPs, AQP1 and AQP4 have been mainly studied in the CNS and evidence has been presented that they play important roles in the pathogenesis of CNS injury, edema and multiple diseases such as multiple sclerosis, neuromyelitis optica spectrum disorders, amyotrophic lateral sclerosis, glioblastoma multiforme, Alzheimer’s disease and Parkinson’s disease. The objective of this review is to highlight the current knowledge about AQPs in the spinal cord and their proposed roles in pathophysiology and pathogenesis related to spinal cord lesions and injury. View Full-Text
Keywords: aquaporin; spinal cord; astrocytes; neurons; endothelial cells; central nervous system; peripheral nerve aquaporin; spinal cord; astrocytes; neurons; endothelial cells; central nervous system; peripheral nerve
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Oklinski, M.K.; Skowronski, M.T.; Skowronska, A.; Rützler, M.; Nørgaard, K.; Nieland, J.D.; Kwon, T.-H.; Nielsen, S. Aquaporins in the Spinal Cord. Int. J. Mol. Sci. 2016, 17, 2050.

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