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Open AccessCommunication
Int. J. Mol. Sci. 2016, 17(12), 1997; doi:10.3390/ijms17121997

Mechanisms of p53 Functional De-Regulation: Role of the IκB-α/p53 Complex

1
Department of Clinical and Biological Sciences, University of Turin, Regione Gonzole 10, 10043 Turin, Italy
2
Department of Oncology, University of Turin, Regione Gonzole 10, 10043 Turin, Italy
*
Author to whom correspondence should be addressed.
Academic Editor: Tomoo Iwakuma
Received: 8 September 2016 / Revised: 23 November 2016 / Accepted: 24 November 2016 / Published: 29 November 2016
(This article belongs to the Special Issue Emerging Non-Canonical Functions and Regulation of p53)
View Full-Text   |   Download PDF [801 KB, uploaded 29 November 2016]   |  

Abstract

TP53 is one of the most frequently-mutated and deleted tumor suppressors in cancer, with a dramatic correlation with dismal prognoses. In addition to genetic inactivation, the p53 protein can be functionally inactivated in cancer, through post-transductional modifications, changes in cellular compartmentalization, and interactions with other proteins. Here, we review the mechanisms of p53 functional inactivation, with a particular emphasis on the interaction between p53 and IκB-α, the NFKBIA gene product. View Full-Text
Keywords: p53; IκB-α; tumor suppressors; functional inactivation p53; IκB-α; tumor suppressors; functional inactivation
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Carrà, G.; Crivellaro, S.; Taulli, R.; Guerrasio, A.; Saglio, G.; Morotti, A. Mechanisms of p53 Functional De-Regulation: Role of the IκB-α/p53 Complex. Int. J. Mol. Sci. 2016, 17, 1997.

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