Mechanisms of p53 Functional De-Regulation: Role of the IκB-α/p53 Complex
AbstractTP53 is one of the most frequently-mutated and deleted tumor suppressors in cancer, with a dramatic correlation with dismal prognoses. In addition to genetic inactivation, the p53 protein can be functionally inactivated in cancer, through post-transductional modifications, changes in cellular compartmentalization, and interactions with other proteins. Here, we review the mechanisms of p53 functional inactivation, with a particular emphasis on the interaction between p53 and IκB-α, the NFKBIA gene product. View Full-Text
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Carrà, G.; Crivellaro, S.; Taulli, R.; Guerrasio, A.; Saglio, G.; Morotti, A. Mechanisms of p53 Functional De-Regulation: Role of the IκB-α/p53 Complex. Int. J. Mol. Sci. 2016, 17, 1997.
Carrà G, Crivellaro S, Taulli R, Guerrasio A, Saglio G, Morotti A. Mechanisms of p53 Functional De-Regulation: Role of the IκB-α/p53 Complex. International Journal of Molecular Sciences. 2016; 17(12):1997.Chicago/Turabian Style
Carrà, Giovanna; Crivellaro, Sabrina; Taulli, Riccardo; Guerrasio, Angelo; Saglio, Giuseppe; Morotti, Alessandro. 2016. "Mechanisms of p53 Functional De-Regulation: Role of the IκB-α/p53 Complex." Int. J. Mol. Sci. 17, no. 12: 1997.
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