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Int. J. Mol. Sci. 2016, 17(12), 1990; doi:10.3390/ijms17121990

Immune-Related Gene Expression Patterns in GPV- or H9N2-Infected Goose Spleens

1,2,3,†,* , 1,†
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1,†
,
3,†
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1,2,3
,
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,
2,3
,
1,2,3
,
1,2,3
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and
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1
Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, China
2
Avian Disease Research Center, College of Veterinary Medicine of Sichuan Agricultural University, Chengdu 611130, China
3
Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Chengdu 611130, China
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Academic Editor: Johannes Haybaeck
Received: 20 September 2016 / Revised: 19 November 2016 / Accepted: 22 November 2016 / Published: 1 December 2016
(This article belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
View Full-Text   |   Download PDF [5682 KB, uploaded 1 December 2016]   |  

Abstract

Goose parvovirus (GPV) and avian influenza virus subtype H9N2 are single-stranded DNA (ssDNA) and single-stranded RNA (ssRNA) viruses, respectively, both of which can spread in goslings and cause a significant economic loss. To explore the comprehensive transcriptome of GPV- or H9N2-infected goose spleens and to understand the immune responses induced by a DNA virus (GPV) or a RNA virus (H9N2), RNA-seq was performed on the spleens of goslings at the fifth day post infection. In the present study, 2604 and 2409 differentially expressed unigenes were identified in the GPV- and H9N2-infected groups, respectively. Through KEGG pathway enrichment analyses, the up-regulated transcripts in the two virus-infected groups were mainly involved in immune-related pathways. In addition, the two virus-infected groups displayed similar expression patterns in the immune response pathways, including pattern-recognition receptor signaling pathways, the antigen processing and presentation pathway, the NF-κB signaling pathway and the JAK-STAT signaling pathway, as well as cytokines. Furthermore, most of the immune-related genes, particularly TLR7, TRAF3, Mx, TRIM25, CD4, and CD8α, increased in response to GPV and H9N2 infection. However, the depression of NF-κB signaling may be a mechanism by which the viruses evade the host immune system or a strategy to achieve immune homeostasis. View Full-Text
Keywords: identical expression profile; systemic transcriptome; GPV; H9N2 identical expression profile; systemic transcriptome; GPV; H9N2
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Chen, S.; Wang, A.; Sun, L.; Liu, F.; Wang, M.; Jia, R.; Zhu, D.; Liu, M.; Yang, Q.; Wu, Y.; Sun, K.; Chen, X.; Cheng, A. Immune-Related Gene Expression Patterns in GPV- or H9N2-Infected Goose Spleens. Int. J. Mol. Sci. 2016, 17, 1990.

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