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Int. J. Mol. Sci. 2016, 17(12), 1974; doi:10.3390/ijms17121974

Future Prospects for Scaffolding Methods and Biomaterials in Skin Tissue Engineering: A Review

Center for Nanobiotechnology Research, Alabama State University, Montgomery, AL 36104, USA
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Academic Editor: John G. Hardy
Received: 7 October 2016 / Revised: 21 November 2016 / Accepted: 22 November 2016 / Published: 25 November 2016
(This article belongs to the Section Biomaterial Sciences)
View Full-Text   |   Download PDF [2605 KB, uploaded 25 November 2016]   |  

Abstract

Over centuries, the field of regenerative skin tissue engineering has had several advancements to facilitate faster wound healing and thereby restoration of skin. Skin tissue regeneration is mainly based on the use of suitable scaffold matrices. There are several scaffold types, such as porous, fibrous, microsphere, hydrogel, composite and acellular, etc., with discrete advantages and disadvantages. These scaffolds are either made up of highly biocompatible natural biomaterials, such as collagen, chitosan, etc., or synthetic materials, such as polycaprolactone (PCL), and poly-ethylene-glycol (PEG), etc. Composite scaffolds, which are a combination of natural or synthetic biomaterials, are highly biocompatible with improved tensile strength for effective skin tissue regeneration. Appropriate knowledge of the properties, advantages and disadvantages of various biomaterials and scaffolds will accelerate the production of suitable scaffolds for skin tissue regeneration applications. At the same time, emphasis on some of the leading challenges in the field of skin tissue engineering, such as cell interaction with scaffolds, faster cellular proliferation/differentiation, and vascularization of engineered tissues, is inevitable. In this review, we discuss various types of scaffolding approaches and biomaterials used in the field of skin tissue engineering and more importantly their future prospects in skin tissue regeneration efforts. View Full-Text
Keywords: scaffolds; biomaterials; synthetic; natural; polymer; skin; wound healing; tissue engineering scaffolds; biomaterials; synthetic; natural; polymer; skin; wound healing; tissue engineering
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Chaudhari, A.A.; Vig, K.; Baganizi, D.R.; Sahu, R.; Dixit, S.; Dennis, V.; Singh, S.R.; Pillai, S.R. Future Prospects for Scaffolding Methods and Biomaterials in Skin Tissue Engineering: A Review. Int. J. Mol. Sci. 2016, 17, 1974.

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Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
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