Int. J. Mol. Sci. 2016, 17(11), 1840; https://doi.org/10.3390/ijms17111840
Transcriptional and Posttranslational Regulation of Nucleotide Excision Repair: The Guardian of the Genome against Ultraviolet Radiation
Department of Biological Science, Dong-A University, Busan 49315, Korea
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Academic Editor: Terrence Piva
Received: 20 September 2016 / Revised: 31 October 2016 / Accepted: 1 November 2016 / Published: 4 November 2016
(This article belongs to the Collection Radiation Toxicity in Cells)
Abstract
Ultraviolet (UV) radiation from sunlight represents a constant threat to genome stability by generating modified DNA bases such as cyclobutane pyrimidine dimers (CPD) and pyrimidine-pyrimidone (6-4) photoproducts (6-4PP). If unrepaired, these lesions can have deleterious effects, including skin cancer. Mammalian cells are able to neutralize UV-induced photolesions through nucleotide excision repair (NER). The NER pathway has multiple components including seven xeroderma pigmentosum (XP) proteins (XPA to XPG) and numerous auxiliary factors, including ataxia telangiectasia and Rad3-related (ATR) protein kinase and RCC1 like domain (RLD) and homologous to the E6-AP carboxyl terminus (HECT) domain containing E3 ubiquitin protein ligase 2 (HERC2). In this review we highlight recent data on the transcriptional and posttranslational regulation of NER activity. View Full-TextKeywords:
ultraviolet radiation; nucleotide excision repair; transcriptional regulation; posttranslational regulation
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Park, J.-M.; Kang, T.-H. Transcriptional and Posttranslational Regulation of Nucleotide Excision Repair: The Guardian of the Genome against Ultraviolet Radiation. Int. J. Mol. Sci. 2016, 17, 1840.
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