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Int. J. Mol. Sci. 2016, 17(11), 1802; doi:10.3390/ijms17111802

A Clinical Trial about a Food Supplement Containing α-Lipoic Acid on Oxidative Stress Markers in Type 2 Diabetic Patients

1
Centre of Diabetes and Metabolic Diseases, Department of Internal Medicine and Therapeutics, University of Pavia and Fondazione IRCCS Policlinico S. Matteo, 2-27100 Pavia, Italy
2
Center for Prevention, Surveillance, Diagnosis and Treatment of Rare Diseases, Fondazione IRCCS Policlinico S. Matteo, 2-27100 Pavia, Italy
3
Center for the Study of Endocrine-Metabolic Pathophysiology and Clinical Research, University of Pavia, 2-27100 Pavia, Italy
4
Laboratory of Molecular Medicine, University of Pavia, 2-27100 Pavia, Italy
5
PhD School in Experimental Medicine, University of Pavia, 2-27100 Pavia, Italy
*
Author to whom correspondence should be addressed.
Academic Editor: David Arráez-Román
Received: 20 August 2016 / Revised: 2 October 2016 / Accepted: 8 October 2016 / Published: 28 October 2016
View Full-Text   |   Download PDF [493 KB, uploaded 28 October 2016]   |  

Abstract

The aim of this study was to evaluate the effect of a food supplement containing α-lipoic acid and of a placebo on glyco-metabolic control and on oxidative stress markers in type 2 diabetics. We randomized 105 diabetics to either a supplementation containing 600 mg of α-lipoic acid, 165 mg of L-carnosin, 7.5 mg of zinc, and vitamins of group B, or a placebo, for three months. We evaluated body mass index, fasting plasma glucose (FPG), post-prandial-glucose (PPG), glycated hemoglobin (HbA1c), fasting plasma insulin (FPI), HOMA-index (HOMA-IR), lipid profile, high sensitivity C-reactive protein (Hs-CRP), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), malondialdehyde (MDA). There was a reduction of FPG, PPG, and HbA1c with the food supplement containing α-lipoic acid compared with a baseline, and with the placebo. Concerning lipid profile, we observed a reduction of LDL-C, and Tg with the food supplement, compared with both the baseline, and the placebo. There was a reduction of Hs-CRP with the food supplement containing α-lipoic acid, both compared with the baseline and the placebo. An increase of SOD, and GSH-Px, and a decrease of MDA were reached by the food supplement containing α-lipoic acid, both compared with the baseline and the placebo. We can conclude that the food supplement containing α-lipoic acid, L-carnosin, zinc, and vitamins of group B improved glycemic control, lipid profile, and anti-oxidative stress markers. View Full-Text
Keywords: α-lipoic acid; L-carnosin; malondialdehyde; oxidative stress α-lipoic acid; L-carnosin; malondialdehyde; oxidative stress
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Derosa, G.; D’Angelo, A.; Romano, D.; Maffioli, P. A Clinical Trial about a Food Supplement Containing α-Lipoic Acid on Oxidative Stress Markers in Type 2 Diabetic Patients. Int. J. Mol. Sci. 2016, 17, 1802.

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