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Int. J. Mol. Sci. 2016, 17(11), 1783; doi:10.3390/ijms17111783

The Control of Calcium Metabolism in Zebrafish (Danio rerio)

1
National Institute for Basic Biology, National Institutes of Natural Sciences, Okazaki, Aichi 444-8787, Japan
2
Institute of Cellular and Organismic Biology, Academia Sinica, Taipei 11529, Taiwan
*
Author to whom correspondence should be addressed.
Academic Editor: ChulHee Kang
Received: 26 September 2016 / Revised: 18 October 2016 / Accepted: 19 October 2016 / Published: 26 October 2016
(This article belongs to the Special Issue Calcium Regulation and Sensing)
View Full-Text   |   Download PDF [1663 KB, uploaded 26 October 2016]   |  

Abstract

Zebrafish is an emerging model for the research of body fluid ionic homeostasis. In this review, we focus on current progress on the regulation of Ca2+ uptake in the context of Ca2+ sensing and hormonal regulation in zebrafish. Na+-K+-ATPase-rich cells (NaRCs), the specialized ionocytes in the embryonic skin and adult gills, play a dominant role in Ca2+ uptake in zebrafish. Transepithelial Ca2+ transport in NaRC, through apical epithelial Ca2+ channels (ECaC), basolateral plasma membrane Ca2+-ATPase (PMCA), and Na+/Ca2+ exchanger (NCX), is analogous to mammalian renal and intestinal Ca2+-absorption cells. Several hormones were demonstrated to differentially regulate Ca2+ uptake through modulating the expression of Ca2+ transporters and/or the proliferation/differentiation of NaRC in zebrafish. In addition, the counterbalance among these hormones is associated with the maintenance of body fluid Ca2+ homeostasis. Calcium-sensing receptor (CaSR) is expressed in several hormone-secreting tissues in zebrafish, and activated CaSR differentially controls calciotropic hormones. The major principles of Ca2+ transport and the hormonal control appear to be conserved from zebrafish to other vertebrates including mammals. The new knowledge gained from zebrafish studies provides new insights into the related issues in vertebrates. View Full-Text
Keywords: calcium; ionocyte; hormone; zebrafish calcium; ionocyte; hormone; zebrafish
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Lin, C.-H.; Hwang, P.-P. The Control of Calcium Metabolism in Zebrafish (Danio rerio). Int. J. Mol. Sci. 2016, 17, 1783.

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