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Int. J. Mol. Sci. 2016, 17(10), 1725; doi:10.3390/ijms17101725

A Personalized Approach in Progressive Multiple Sclerosis: The Current Status of Disease Modifying Therapies (DMTs) and Future Perspectives

Multiple Sclerosis Center, Policlinico G. Rodolico, via Santa Sofia, 78 Catania 95123, Italy
Author to whom correspondence should be addressed.
Academic Editor: William Chi-shing Cho
Received: 21 July 2016 / Revised: 29 September 2016 / Accepted: 2 October 2016 / Published: 17 October 2016
(This article belongs to the Special Issue Precision Medicine—From Bench to Bedside)
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Using the term of progressive multiple sclerosis (PMS), we considered a combined population of persons with secondary progressive MS (SPMS) and primary progressive MS (PPMS). These forms of MS cannot be challenged with efficacy by the licensed therapy. In the last years, several measures of risk estimation were developed for predicting clinical course in MS, but none is specific for the PMS forms. Personalized medicine is a therapeutic approach, based on identifying what might be the best therapy for an individual patient, taking into account the risk profile. We need to achieve more accurate estimates of useful predictors in PMS, including unconventional and qualitative markers which are not yet currently available or practicable routine diagnostics. The evaluation of an individual patient is based on the profile of disease activity.Within the neurology field, PMS is one of the fastest-moving going into the future. View Full-Text
Keywords: personalized treatment; progressive multiple sclerosis; future perspectives personalized treatment; progressive multiple sclerosis; future perspectives

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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D’Amico, E.; Patti, F.; Zanghì, A.; Zappia, M. A Personalized Approach in Progressive Multiple Sclerosis: The Current Status of Disease Modifying Therapies (DMTs) and Future Perspectives. Int. J. Mol. Sci. 2016, 17, 1725.

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