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Int. J. Mol. Sci. 2016, 17(10), 1650; doi:10.3390/ijms17101650

EpCAM Expression in Lymph Node and Bone Metastases of Prostate Carcinoma: A Pilot Study

1
Laboratory of Neuroimmunology, National Institute of Neurology and Neurosurgery “Manuel Velasco Suárez”, Avenida Insurgentes Sur 3877, La Fama, Tlalpan, 14269 Mexico City, Mexico
2
Department of Urology, University Medical Center Groningen, University of Groningen, P.O. Box 30.001, Groningen 9700 RB, The Netherlands
3
Department of Pathology, University Medical Center Groningen, University of Groningen, P.O. Box 30.001, Groningen 9700 RB, The Netherlands
4
Department of Pathology, Josephine Nefkens Institute, Erasmus MC, P.O. Box 2040, Rotterdam 3000 CA, The Netherlands
*
Author to whom correspondence should be addressed.
Academic Editor: Carsten Stephan
Received: 12 June 2016 / Revised: 11 September 2016 / Accepted: 15 September 2016 / Published: 29 September 2016
(This article belongs to the Special Issue Diagnostic, Prognostic and Predictive Biomarkers in Prostate Cancer)
View Full-Text   |   Download PDF [2081 KB, uploaded 29 September 2016]   |  

Abstract

There is an urgent need for new imaging modalities in prostate carcinoma staging. A non-invasive modality that can assess lymph node and bone metastases simultaneously is preferred. Epithelial cell adhesion molecule (EpCAM) is a membranous protein of interest as an imaging target since it is overexpressed in prostatic carcinoma compared with benign prostate epithelium and compared with stroma. However, EpCAM expression in lymph node metastases is sparsely available in the literature and EpCAM expression in bone metastases is yet unknown. The current study evaluates the expression of EpCAM in prostate carcinoma lymph nodes, in matched normal lymph nodes, in prostate carcinoma bone metastases, and in normal bone by immunohistochemistry. EpCAM was expressed in 100% of lymph node metastases (21 out of 21), in 0% of normal lymph nodes (0 out of 21), in 95% of bone metastases (19 out of 20), and in 0% of normal bone (0 out of 14). Based on these results, EpCAM may be a feasible imaging target in prostate carcinoma lymph node and bone metastases. Prospective clinical trials are needed to confirm current results. Preoperative visualization of prostate carcinoma metastases will improve disease staging and will prevent unnecessary invasive surgery. View Full-Text
Keywords: molecular imaging; imaging target; prostate carcinoma; metastases; epithelial cell adhesion molecule (EpCAM); immunohistochemistry molecular imaging; imaging target; prostate carcinoma; metastases; epithelial cell adhesion molecule (EpCAM); immunohistochemistry
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MDPI and ACS Style

Campos, A.K.; Hoving, H.D.; Rosati, S.; van Leenders, G.J.L.H.; de Jong, I.J. EpCAM Expression in Lymph Node and Bone Metastases of Prostate Carcinoma: A Pilot Study. Int. J. Mol. Sci. 2016, 17, 1650.

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