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Int. J. Mol. Sci. 2016, 17(1), 93; doi:10.3390/ijms17010093

miRNAs Regulation and Its Role as Biomarkers in Endometriosis

1
Unit of Hemostasia, Thrombosis, Atherosclerosis and Vascular Biology, Health Research Institute La Fe, Valencia 46026, Spain
2
Arrays Unit, Health Research Institute La Fe, Valencia 46026, Spain
3
Maternal Child Area, General Hospital, Valencia 46014, Spain
4
Epigomics Unit, Health Research Institute La Fe, Valencia 46026, Spain
These authors contributed equally to this work.
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Academic Editors: Nalini Santanam and William Chi-shing Cho
Received: 21 December 2015 / Revised: 5 January 2016 / Accepted: 8 January 2016 / Published: 13 January 2016
(This article belongs to the Special Issue MicroRNA in Various Disease States as Biomarkers)
View Full-Text   |   Download PDF [1134 KB, uploaded 13 January 2016]   |  

Abstract

MicroRNAs (miRNAs) are small non-coding RNAs (18–22 nt) that function as modulators of gene expression. Since their discovery in 1993 in C. elegans, our knowledge about their biogenesis, function, and mechanism of action has increased enormously, especially in recent years, with the development of deep-sequencing technologies. New biogenesis pathways and sources of miRNAs are changing our concept about these molecules. The study of the miRNA contribution to pathological states is a field of great interest in research. Different groups have reported the implication of miRNAs in pathologies such as cancer, diabetes, cardiovascular, and gynecological diseases. It is also well-known that miRNAs are present in biofluids (plasma, serum, urine, semen, and menstrual blood) and have been proposed as ideal candidates as disease biomarkers. The goal of this review is to highlight the current knowledge in the field of miRNAs with a special emphasis to their role in endometriosis and the newest investigations addressing the use of miRNAs as biomarkers for this gynecological disease. View Full-Text
Keywords: non-coding RNA; microRNA; biomarker; endometriosis non-coding RNA; microRNA; biomarker; endometriosis
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Marí-Alexandre, J.; Sánchez-Izquierdo, D.; Gilabert-Estellés, J.; Barceló-Molina, M.; Braza-Boïls, A.; Sandoval, J. miRNAs Regulation and Its Role as Biomarkers in Endometriosis. Int. J. Mol. Sci. 2016, 17, 93.

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