miRNAs Regulation and Its Role as Biomarkers in Endometriosis
AbstractMicroRNAs (miRNAs) are small non-coding RNAs (18–22 nt) that function as modulators of gene expression. Since their discovery in 1993 in C. elegans, our knowledge about their biogenesis, function, and mechanism of action has increased enormously, especially in recent years, with the development of deep-sequencing technologies. New biogenesis pathways and sources of miRNAs are changing our concept about these molecules. The study of the miRNA contribution to pathological states is a field of great interest in research. Different groups have reported the implication of miRNAs in pathologies such as cancer, diabetes, cardiovascular, and gynecological diseases. It is also well-known that miRNAs are present in biofluids (plasma, serum, urine, semen, and menstrual blood) and have been proposed as ideal candidates as disease biomarkers. The goal of this review is to highlight the current knowledge in the field of miRNAs with a special emphasis to their role in endometriosis and the newest investigations addressing the use of miRNAs as biomarkers for this gynecological disease. View Full-Text
Share & Cite This Article
Marí-Alexandre, J.; Sánchez-Izquierdo, D.; Gilabert-Estellés, J.; Barceló-Molina, M.; Braza-Boïls, A.; Sandoval, J. miRNAs Regulation and Its Role as Biomarkers in Endometriosis. Int. J. Mol. Sci. 2016, 17, 93.
Marí-Alexandre J, Sánchez-Izquierdo D, Gilabert-Estellés J, Barceló-Molina M, Braza-Boïls A, Sandoval J. miRNAs Regulation and Its Role as Biomarkers in Endometriosis. International Journal of Molecular Sciences. 2016; 17(1):93.Chicago/Turabian Style
Marí-Alexandre, Josep; Sánchez-Izquierdo, Dolors; Gilabert-Estellés, Juan; Barceló-Molina, Moisés; Braza-Boïls, Aitana; Sandoval, Juan. 2016. "miRNAs Regulation and Its Role as Biomarkers in Endometriosis." Int. J. Mol. Sci. 17, no. 1: 93.
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.