Next Article in Journal
Pharmacotherapy Treatment Options for Insomnia: A Primer for Clinicians
Next Article in Special Issue
Identification of Serum Peptidome Signatures of Non-Small Cell Lung Cancer
Previous Article in Journal
Innovative Target Therapies Are Able to Block the Inflammation Associated with Dysfunction of the Cholesterol Biosynthesis Pathway
Previous Article in Special Issue
Alisertib Induces Cell Cycle Arrest, Apoptosis, Autophagy and Suppresses EMT in HT29 and Caco-2 Cells
Article Menu
Issue 1 (January) cover image

Export Article

Open AccessReview
Int. J. Mol. Sci. 2016, 17(1), 48; doi:10.3390/ijms17010048

Notch Signaling in Pancreatic Development

1
College of Life Science, Northeast Forestry University, Harbin 150040, China
2
College of Life Sciences, Agriculture and Forestry, Qiqihar University, Qiqihar 161006, China
*
Author to whom correspondence should be addressed.
Academic Editor: William Chi-shing Cho
Received: 22 November 2015 / Revised: 22 December 2015 / Accepted: 24 December 2015 / Published: 30 December 2015
(This article belongs to the Special Issue Molecular Classification of Human Cancer: Diagnosis and Treatment)
View Full-Text   |   Download PDF [1620 KB, uploaded 30 December 2015]   |  

Abstract

The Notch signaling pathway plays a significant role in embryonic cell fate determination and adult tissue homeostasis. Various studies have demonstrated the deep involvement of Notch signaling in the development of the pancreas and the lateral inhibition of Notch signaling in pancreatic progenitor differentiation and maintenance. The targeted inactivation of the Notch pathway components promotes premature differentiation of the endocrine pancreas. However, there is still the contrary opinion that Notch signaling specifies the endocrine lineage. Here, we review the current knowledge of the Notch signaling pathway in pancreatic development and its crosstalk with the Wingless and INT-1 (Wnt) and fibroblast growth factor (FGF) pathways. View Full-Text
Keywords: pancreatic progenitor; Notch signaling; differentiation; maintenance pancreatic progenitor; Notch signaling; differentiation; maintenance
Figures

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Li, X.-Y.; Zhai, W.-J.; Teng, C.-B. Notch Signaling in Pancreatic Development. Int. J. Mol. Sci. 2016, 17, 48.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top