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Int. J. Mol. Sci. 2016, 17(1), 32; doi:10.3390/ijms17010032

In Vivo Anti-Tumor Activity and Toxicological Evaluations of Perillaldehyde 8,9-Epoxide, a Derivative of Perillyl Alcohol

1
Departamento de Fisiologia, Universidade Federal de Sergipe, CEP 49100-000, São Cristóvão, Sergipe CP 353, Brazil
2
Laboratório de Morfologia e Patologia Experimental, Instituto de Tecnologia e Pesquisa, CEP 49032-490, Aracaju, Sergipe CP 203, Brazil
3
Departamento de Ciências Farmacêuticas, Universidade Federal da Paraíba, CEP 58051-970, João Pessoa, Paraíba CP 5009, Brazil
4
Núcleo de Farmácia, Universidade Federal de Sergipe, CEP 49400-000, Lagarto, Sergipe CP 353, Brazil
*
Author to whom correspondence should be addressed.
Academic Editor: Sanjay K. Srivastava
Received: 14 July 2015 / Revised: 24 October 2015 / Accepted: 2 November 2015 / Published: 4 January 2016
(This article belongs to the Section Biochemistry, Molecular and Cellular Biology)
View Full-Text   |   Download PDF [9370 KB, uploaded 4 January 2016]   |  

Abstract

Recent studies have revealed the high cytotoxicity of p-menthane derivatives against human tumor cells. In this study, the substance perillaldehyde 8,9-epoxide, a p-menthane class derivative obtained from (S)-(−)-perillyl alcohol, was selected in order to assess antitumor activity against experimental sarcoma 180 tumors. Toxicological effects related to the liver, spleen, kidneys and hematology were evaluated in mice submitted to treatment. The tumor growth inhibition rate was 38.4%, 58.7%, 35.3%, 45.4% and 68.1% at doses of 100 and 200 mg/kg/day for perillaldehyde 8,9-epoxide, perillyl alcohol and 25 mg/kg/day for 5-FU intraperitoneal treatments, respectively. No toxicologically significant effect was found in liver and kidney parameters analyzed in Sarcoma 180-inoculated mice treated with perillaldehyde 8,9-epoxide. Histopathological analyses of the liver, spleen, and kidneys were free from any morphological changes in the organs of the animals treated with perillaldehyde 8,9-epoxide. In conclusion, the data suggest that perillaldehyde 8,9-epoxide possesses significant antitumor activity without systemic toxicity for the tested parameters. By comparison, there was no statistical difference for the antitumor activity between perillaldehyde 8,9-epoxide and perillyl alcohol. View Full-Text
Keywords: p-menthanes; monoterpenes; essential oils; natural products; antitumor activity; sarcoma 180; toxicity; anticancer; perillyl alcohol p-menthanes; monoterpenes; essential oils; natural products; antitumor activity; sarcoma 180; toxicity; anticancer; perillyl alcohol
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Andrade, L.N.; Amaral, R.G.; Dória, G.A.A.; Fonseca, C.S.; da Silva, T.K.M.; Albuquerque Júnior, R.L.C.; Thomazzi, S.M.; do Nascimento, L.G.; Carvalho, A.A.; de Sousa, D.P. In Vivo Anti-Tumor Activity and Toxicological Evaluations of Perillaldehyde 8,9-Epoxide, a Derivative of Perillyl Alcohol. Int. J. Mol. Sci. 2016, 17, 32.

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