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Int. J. Mol. Sci. 2016, 17(1), 26; doi:10.3390/ijms17010026

Targeting New Candidate Genes by Small Molecules Approaching Neurodegenerative Diseases

1
Department of Pediatrics, Tung’s Taichung Metroharbor Hospital, Wuchi, Taichung 435, Taiwan
2
Department of Nursing, Jen-Teh Junior College of Medicine, Nursing and Management, Miaoli 356, Taiwan
3
Department of Pediatrics, Taichung Veterans General Hospital, Taichung 407, Taiwan
4
School of Medicine, Chung Shan Medical University, Taichung 402, Taiwan
5
Department of Pediatrics, Chung Shan Medical University Hospital, Taichung 402, Taiwan
6
Graduate Institute of Immunology, China Medical University, Taichung 404, Taiwan
7
Center for Neuropsychiatry, China Medical University and Hospital, Taichung 404, Taiwan
8
Department of Neurosurgery, China Medical University Beigang Hospital, Yunlin 651, Taiwan
9
Department of Pathology, China Medical University and Hospital, Taichung 404, Taiwan
*
Author to whom correspondence should be addressed.
Academic Editor: Kurt A. Jellinger
Received: 6 October 2015 / Revised: 10 December 2015 / Accepted: 21 December 2015 / Published: 25 December 2015
(This article belongs to the Special Issue Mechanisms of Neurodegeneration)
View Full-Text   |   Download PDF [742 KB, uploaded 25 December 2015]   |  

Abstract

Neurodegenerative diseases (NDs) are among the most feared of the disorders that afflict humankind for the lack of specific diagnostic tests and effective treatments. Understanding the molecular, cellular, biochemical changes of NDs may hold therapeutic promise against debilitating central nerve system (CNS) disorders. In the present review, we summarized the clinical presentations and biology backgrounds of NDs, including Parkinson’s disease (PD), Huntington’s disease (HD), and Alzheimer’s disease (AD) and explored the role of molecular mechanisms, including dys-regulation of epigenetic control mechanisms, Ataxia-telangiectasia-mutated protein kinase (ATM), and neuroinflammation in the pathogenesis of NDs. Targeting these mechanisms may hold therapeutic promise against these devastating diseases. View Full-Text
Keywords: neurodegenerative diseases (NDs); Parkinson’s disease (PD); Huntington’s disease (HD); Alzheimer’s disease (AD); epigenetics; Ataxia-telangiectasia-mutated protein kinase (ATM); neuroinflammation neurodegenerative diseases (NDs); Parkinson’s disease (PD); Huntington’s disease (HD); Alzheimer’s disease (AD); epigenetics; Ataxia-telangiectasia-mutated protein kinase (ATM); neuroinflammation
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MDPI and ACS Style

Fan, H.-C.; Chi, C.-S.; Cheng, S.-N.; Lee, H.-F.; Tsai, J.-D.; Lin, S.-Z.; Harn, H.-J. Targeting New Candidate Genes by Small Molecules Approaching Neurodegenerative Diseases. Int. J. Mol. Sci. 2016, 17, 26.

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