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Int. J. Mol. Sci. 2016, 17(1), 16; doi:10.3390/ijms17010016

Epigenetic Regulation of Epidermal Stem Cell Biomarkers and Their Role in Wound Healing

1
Department of Biological Sciences, Alabama State University, Montgomery, AL 36104, USA
2
Department of Biology, University of Alabama at Birmingham, Birmingham, AL 35294-1170, USA
3
Clinical Nutrition Research Center, University of Alabama at Birmingham, Birmingham, AL 35294-1170, USA
4
Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, AL 35294-1170, USA
5
Center for Aging, University of Alabama at Birmingham, Birmingham, AL 35294-1170, USA
6
Nutrition Obesity Research Center, University of Alabama at Birmingham, Birmingham, AL 35294-1170, USA
*
Author to whom correspondence should be addressed.
Academic Editor: William Chi-shing Cho
Received: 7 November 2015 / Revised: 11 December 2015 / Accepted: 16 December 2015 / Published: 24 December 2015
(This article belongs to the Section Biochemistry, Molecular and Cellular Biology)
View Full-Text   |   Download PDF [681 KB, uploaded 24 December 2015]   |  

Abstract

As an actively renewable tissue, changes in skin architecture are subjected to the regulation of stem cells that maintain the population of cells responsible for the formation of epidermal layers. Stems cells retain their self-renewal property and express biomarkers that are unique to this population. However, differential regulation of the biomarkers can initiate the pathway of terminal cell differentiation. Although, pockets of non-clarity in stem cell maintenance and differentiation in skin still exist, the influence of epigenetics in epidermal stem cell functions and differentiation in skin homeostasis and wound healing is clearly evident. The focus of this review is to discuss the epigenetic regulation of confirmed and probable epidermal stem cell biomarkers in epidermal stratification of normal skin and in diseased states. The role of epigenetics in wound healing, especially in diseased states of diabetes and cancer, will also be conveyed. View Full-Text
Keywords: epigenetics; wound healing; skin; microRNA; epidermal stem cells; biomarkers epigenetics; wound healing; skin; microRNA; epidermal stem cells; biomarkers
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Saldanha, S.N.; Royston, K.J.; Udayakumar, N.; Tollefsbol, T.O. Epigenetic Regulation of Epidermal Stem Cell Biomarkers and Their Role in Wound Healing. Int. J. Mol. Sci. 2016, 17, 16.

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Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
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