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Int. J. Mol. Sci. 2016, 17(1), 135; doi:10.3390/ijms17010135

Photodynamic Therapy in Non-Gastrointestinal Thoracic Malignancies

1
Division of Thoracic Surgery, University of Toronto, Toronto, ON M5G 2C4, Canada
2
Division of Thoracic Surgery, Toronto General Hospital, Toronto, ON M5G 2C4, Canada
3
Faculty of Medicine, University of Toronto, Toronto, ON M5S 1A8, Canada
*
Author to whom correspondence should be addressed.
Academic Editor: Ying-ying Huang
Received: 28 November 2015 / Revised: 13 January 2016 / Accepted: 18 January 2016 / Published: 21 January 2016
(This article belongs to the Special Issue Advances in Photodynamic Therapy)
View Full-Text   |   Download PDF [1220 KB, uploaded 21 January 2016]   |  

Abstract

Photodynamic therapy has a role in the management of early and late thoracic malignancies. It can be used to facilitate minimally-invasive treatment of early endobronchial tumours and also to palliate obstructive and bleeding effects of advanced endobronchial tumours. Photodynamic therapy has been used as a means of downsizing tumours to allow for resection, as well as reducing the extent of resection necessary. It has also been used successfully for minimally-invasive management of local recurrences, which is especially valuable for patients who are not eligible for radiation therapy. Photodynamic therapy has also shown promising results in mesothelioma and pleural-based metastatic disease. As new generation photosensitizers are being developed and tested and methodological issues continue to be addressed, the role of photodynamic therapy in thoracic malignancies continues to evolve. View Full-Text
Keywords: photodynamic therapy; non-small cell lung cancer; thoracic malignancy; mesothelioma; bronchial obstruction; airway obstruction; pleural metastasis photodynamic therapy; non-small cell lung cancer; thoracic malignancy; mesothelioma; bronchial obstruction; airway obstruction; pleural metastasis
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Kidane, B.; Hirpara, D.; Yasufuku, K. Photodynamic Therapy in Non-Gastrointestinal Thoracic Malignancies. Int. J. Mol. Sci. 2016, 17, 135.

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