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Int. J. Mol. Sci. 2016, 17(1), 124; doi:10.3390/ijms17010124

Molecular Regulation of Adipogenesis and Potential Anti-Adipogenic Bioactive Molecules

1
Department of Animal Science, University of Manitoba, 201 Animal Science building, Winnipeg, MB R3T 2N2, Canada
2
Department of Poultry Science, University of Georgia, 303 Poultry Science Building, Athens, GA 30602-2772, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Giovanni Tarantino
Received: 3 December 2015 / Revised: 27 December 2015 / Accepted: 7 January 2016 / Published: 19 January 2016
(This article belongs to the Section Biochemistry, Molecular and Cellular Biology)
View Full-Text   |   Download PDF [499 KB, uploaded 19 January 2016]   |  

Abstract

Adipogenesis is the process by which precursor stem cells differentiate into lipid laden adipocytes. Adipogenesis is regulated by a complex and highly orchestrated gene expression program. In mammalian cells, the peroxisome proliferator-activated receptor γ (PPARγ), and the CCAAT/enhancer binding proteins (C/EBPs) such as C/EBPα, β and δ are considered the key early regulators of adipogenesis, while fatty acid binding protein 4 (FABP4), adiponectin, and fatty acid synthase (FAS) are responsible for the formation of mature adipocytes. Excess accumulation of lipids in the adipose tissue leads to obesity, which is associated with cardiovascular diseases, type II diabetes and other pathologies. Thus, investigating adipose tissue development and the underlying molecular mechanisms is vital to develop therapeutic agents capable of curbing the increasing incidence of obesity and related pathologies. In this review, we address the process of adipogenic differentiation, key transcription factors and proteins involved, adipogenic regulators and potential anti-adipogenic bioactive molecules. View Full-Text
Keywords: adipogenesis; PPARγ; C/EBPα; adipose tissue; obesity adipogenesis; PPARγ; C/EBPα; adipose tissue; obesity
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Moseti, D.; Regassa, A.; Kim, W.-K. Molecular Regulation of Adipogenesis and Potential Anti-Adipogenic Bioactive Molecules. Int. J. Mol. Sci. 2016, 17, 124.

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