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Int. J. Mol. Sci. 2016, 17(1), 10; doi:10.3390/ijms17010010

Research Advances on Pathways of Nickel-Induced Apoptosis

1,†
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1,†
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1,2,* , 1,2
,
1,2
,
1,2
,
1,2
,
1,2
and
1
1
Key Laboratory of Animal Diseases and Environmental Hazards of Sichuan Province, Sichuan Agricultural University, Ya’an 625014, China
2
College of Veterinary Medicine, Sichuan Agricultural University Ya’an, Ya’an 625014, China
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editor: Anthony Lemarié
Received: 22 September 2015 / Revised: 15 December 2015 / Accepted: 16 December 2015 / Published: 23 December 2015
(This article belongs to the Collection Programmed Cell Death and Apoptosis)
View Full-Text   |   Download PDF [1704 KB, uploaded 28 December 2015]   |  

Abstract

High concentrations of nickel (Ni) are harmful to humans and animals. Ni targets a number of organs and produces multiple toxic effects. Apoptosis is important in Ni-induced toxicity of the kidneys, liver, nerves, and immune system. Apoptotic pathways mediated by reactive oxygen species (ROS), mitochondria, endoplasmic reticulum (ER), Fas, and c-Myc participate in Ni-induced cell apoptosis. However, the exact mechanism of apoptosis caused by Ni is still unclear. Understanding the mechanism of Ni-induced apoptosis may help in designing measures to prevent Ni toxicity. View Full-Text
Keywords: Ni; apoptosis; molecular mechanism; mitochondria; endoplasmic reticulum Ni; apoptosis; molecular mechanism; mitochondria; endoplasmic reticulum
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Guo, H.; Chen, L.; Cui, H.; Peng, X.; Fang, J.; Zuo, Z.; Deng, J.; Wang, X.; Wu, B. Research Advances on Pathways of Nickel-Induced Apoptosis. Int. J. Mol. Sci. 2016, 17, 10.

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