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Int. J. Mol. Sci. 2016, 17(1), 9; doi:10.3390/ijms17010009

Characteristics of Antisense Transcript Promoters and the Regulation of Their Activity

1,2,3
,
1,2,3,4
,
1,2,3
and
1,2,3,*
1
Department of Animal Genetics, Breeding and Reproduction, College of Animal Science, South China Agricultural University, Guangzhou 510642, China
2
Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding, Guangzhou 510642, China
3
Key Lab of Chicken Genetics, Breeding and Reproduction, Ministry of Agriculture, Guangzhou 510642, China
4
Agricultural College, Guangdong Ocean University, Zhanjiang 524088, China
*
Author to whom correspondence should be addressed.
Academic Editor: Kotb Abdelmohsen
Received: 19 October 2015 / Revised: 23 November 2015 / Accepted: 16 December 2015 / Published: 23 December 2015
(This article belongs to the Section Biochemistry, Molecular and Cellular Biology)
View Full-Text   |   Download PDF [1080 KB, uploaded 23 December 2015]   |  

Abstract

Recently, an increasing number of studies on natural antisense transcripts have been reported, especially regarding their classification, temporal and spatial expression patterns, regulatory functions and mechanisms. It is well established that natural antisense transcripts are produced from the strand opposite to the strand encoding a protein. Despite the pivotal roles of natural antisense transcripts in regulating the expression of target genes, the transcriptional mechanisms initiated by antisense promoters (ASPs) remain unknown. To date, nearly all of the studies conducted on this topic have focused on the ASP of a single gene of interest, whereas no study has systematically analyzed the locations of ASPs in the genome, ASP activity, or factors influencing this activity. This review focuses on elaborating on and summarizing the characteristics of ASPs to extend our knowledge about the mechanisms of antisense transcript initiation. View Full-Text
Keywords: antisense promoter; location; characteristics; activity; influencing factors antisense promoter; location; characteristics; activity; influencing factors
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Lin, S.; Zhang, L.; Luo, W.; Zhang, X. Characteristics of Antisense Transcript Promoters and the Regulation of Their Activity. Int. J. Mol. Sci. 2016, 17, 9.

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