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Int. J. Mol. Sci. 2015, 16(9), 22927-22937; doi:10.3390/ijms160922927

Effects of Microcystin-LR Exposure on Spermiogenesis in Nematode Caenorhabditis elegans

1
Key Laboratory of Environmental Medicine Engineering Ministry of Education, School of Public Health, Southeast University, Nanjing 210009, China
2
Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Anna Cristina S. Samia
Received: 13 June 2015 / Revised: 17 August 2015 / Accepted: 15 September 2015 / Published: 22 September 2015
(This article belongs to the Section Molecular Toxicology)
View Full-Text   |   Download PDF [229 KB, uploaded 22 September 2015]   |  

Abstract

Little is known about the effect on spermiogenesis induced by microcystin-leucine arginine (MC-LR), even though such data are very important to better elucidate reproductive health. In the current work, with the aid of nematode Caenorhabditis elegans (C. elegans) as an animal model, we investigated the defects on spermiogenesis induced by MC-LR. Our results showed that MC-LR exposure induced sperm morphology abnormality and caused severe defects of sperm activation, trans-activation, sperm behavior and competition. Additionally, the expression levels of spe-15 were significantly decreased in C. elegans exposed to MC-LR lower than 16.0 μg/L, while the expression levels of spe-10 and fer-1 could be significantly lowered in C. elegans even exposed to 1.0 μg/L of MC-LR. Therefore, the present study reveals that MC-LR can induce adverse effects on spermiogenesis, and those defects of sperm functions may be induced by the decreases of spe-10, spe-15 and fer-1 gene expressions in C. elegans. View Full-Text
Keywords: Caenorhabditis elegans; microcystin-LR; spermiogenesis; reproductive toxicity Caenorhabditis elegans; microcystin-LR; spermiogenesis; reproductive toxicity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Li, Y.; Zhang, M.; Chen, P.; Liu, R.; Liang, G.; Yin, L.; Pu, Y. Effects of Microcystin-LR Exposure on Spermiogenesis in Nematode Caenorhabditis elegans. Int. J. Mol. Sci. 2015, 16, 22927-22937.

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