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Int. J. Mol. Sci. 2015, 16(9), 22754-22780; doi:10.3390/ijms160922754

Interaction of DNA with Simple and Mixed Ligand Copper(II) Complexes of 1,10-Phenanthrolines as Studied by DNA-Fiber EPR Spectroscopy

1
Department of Applied Chemistry, Chuo University, Kasuga, Bunkyou-ku, Tokyo 112-8551, Japan
2
Department of Pharmaceutical Chemistry, International Medical University, Kuala Lumpur 57000, Malaysia
3
Department of Chemistry, Indian Institute of Technology Bombay, Powai, Mumbai 400 076, India
*
Author to whom correspondence should be addressed.
Academic Editor: Eric C. Long
Received: 30 July 2015 / Revised: 30 August 2015 / Accepted: 9 September 2015 / Published: 21 September 2015
(This article belongs to the Special Issue Low Molecular Weight DNA and RNA Binding Agents)
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Abstract

The interaction of simple and ternary Cu(II) complexes of 1,10-phenanthrolines with DNA has been studied extensively because of their various interesting and important functions such as DNA cleavage activity, cytotoxicity towards cancer cells, and DNA based asymmetric catalysis. Such functions are closely related to the DNA binding modes of the complexes such as intercalation, groove binding, and electrostatic surface binding. A variety of spectroscopic methods have been used to study the DNA binding mode of the Cu(II) complexes. Of all these methods, DNA-fiber electron paramagnetic resonance (EPR) spectroscopy affords unique information on the DNA binding structures of the complexes. In this review we summarize the results of our DNA-fiber EPR studies on the DNA binding structure of the complexes and discuss them together with the data accumulated by using other measurements. View Full-Text
Keywords: electron paramagnetic resonance; DNA fiber; Cu(II) complexes; 1,10-phenanthrolines; DNA binding structures; DNA conformation electron paramagnetic resonance; DNA fiber; Cu(II) complexes; 1,10-phenanthrolines; DNA binding structures; DNA conformation
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Chikira, M.; Ng, C.H.; Palaniandavar, M. Interaction of DNA with Simple and Mixed Ligand Copper(II) Complexes of 1,10-Phenanthrolines as Studied by DNA-Fiber EPR Spectroscopy. Int. J. Mol. Sci. 2015, 16, 22754-22780.

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