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Int. J. Mol. Sci. 2015, 16(9), 21846-21857; doi:10.3390/ijms160921846

A Novel Function of TET2 in CNS: Sustaining Neuronal Survival

1,2,†
,
2,3,†
,
4
,
5
,
1,* and 3,5,*
1
State Key Laboratory of Military Stomatology, Department of Anesthesiology, School of Stomatology, the Fourth Military Medical University, Xi'an 710032, China
2
Institute of Basic Medicine Science, Xi'an Medical University, Xi'an 710021, China
3
School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China
4
Department of Cell and Developmental Biology, University of Colorado Denver, Denver, CO 80045, USA
5
Institute of Nano Biomedicine and Engineering, Department of Instrument Science and Engineering, Key Laboratory for Thin Film and Microfabrication Technology of Ministry of Education, School of Electronic Information and Electronic Engineering, Shanghai Jiao Tong University, Shanghai 200240, China
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Academic Editor: Kurt A. Jellinger
Received: 7 June 2015 / Revised: 19 August 2015 / Accepted: 1 September 2015 / Published: 10 September 2015
(This article belongs to the Section Biochemistry, Molecular and Cellular Biology)
View Full-Text   |   Download PDF [4761 KB, uploaded 10 September 2015]   |  

Abstract

DNA dioxygenases Ten-Eleven Translocation (TET) proteins can catalyze the conversion of 5-methylcytosine (5mC) of DNA to 5-hydroxymethylcytosine (5hmC), and thereby alter the epigenetic state of DNA. The TET family includes TET1, TET2 and TET3 members in mammals. Recently, accumulative research uncovered that TET1–3 occur abundantly in the central nervous system (CNS), and their biological functions have just begun to be investigated. In the present study, we demonstrated that mRNA and protein of TET2 were highly expressed in the cerebral cortex and hippocampus along the whole brain-development process. Further studies showed that TET2 was expressed in various types of cells, especially in most neurons. Subcellular distribution pattern implicated that TET2 is localized in both nucleus and cytoplasm of neurons. Down-regulation of TET2 in cultured cortical neurons with RNA interference implied that TET2 was required for cell survival. In all, our results indicate that neuronal TET2 is positively involved in the regulation of cell survival. View Full-Text
Keywords: TET2; cell survival; CNS; neurons; RNA interference TET2; cell survival; CNS; neurons; RNA interference
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Mi, Y.; Gao, X.; Dai, J.; Ma, Y.; Xu, L.; Jin, W. A Novel Function of TET2 in CNS: Sustaining Neuronal Survival. Int. J. Mol. Sci. 2015, 16, 21846-21857.

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