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Int. J. Mol. Sci. 2015, 16(9), 21539-21554; doi:10.3390/ijms160921539

Polymorphisms in the LPL and CETP Genes and Haplotype in the ESR1 Gene Are Associated with Metabolic Syndrome in Women from Southwestern Mexico

1
Laboratorio de Investigación en Epidemiología Clínica y Molecular, Unidad Académica de Ciencias Químico Biológicas, Universidad Autónoma de Guerrero, Chilpancingo, Guerrero 39089, Mexico
2
Unidad de Investigación Médica en Bioquímica, Hospital de Especialidades "Bernardo Sepúlveda", Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Distrito Federal 06725, Mexico
3
Laboratorio de Biomedicina Molecular, Unidad Académica de Ciencias Químico Biológicas, Universidad Autónoma de Guerrero, Chilpancingo, Guerrero 39089, Mexico
4
Department of Anthropology, University of Toronto at Mississauga, Mississauga, ON L5L 1C6, Canada
*
Author to whom correspondence should be addressed.
Academic Editor: Emil Alexov
Received: 8 June 2015 / Revised: 20 July 2015 / Accepted: 24 July 2015 / Published: 8 September 2015
(This article belongs to the Collection Human Single Nucleotide Polymorphisms and Disease Diagnostics)
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Abstract

Metabolic syndrome (MetS) is a combination of metabolic disorders associated with an increased risk for cardiovascular disease (CVD). Studies in women reported associations between polymorphisms in ESR1, LPL and CETP genes and MetS. Our aim was to evaluate the association between variants in ESR1, LPL and CETP genes with MetS and its components. Four hundred and eighty women were analyzed, anthropometric features and biochemical profiles were evaluated, and genotyping was performed by real-time PCR. We found an association with elevated glucose levels (odds ratio (OR) = 2.9; p = 0.013) in carrying the AA genotype of rs1884051 in the ESR1 gene compared with the GG genotype, and the CC genotype of rs328 in the LPL gene was associated with MetS compared to the CG or GG genotype (OR = 2.8; p = 0.04). Moreover, the GA genotype of rs708272 in the CETP gene is associated with MetS compared to the GG or AA genotype (OR = 1.8; p = 0.006). In addition the ACTCCG haplotype in the ESR1 gene is associated with a decrease in the risk of MetS (OR = 0.02; p < 0.001). In conclusion, our results show the involvement of the variants of ESR1, LPL and CETP genes in metabolic events related to MetS or some of its features. View Full-Text
Keywords: metabolic syndrome; LPL and CETP polymorphisms; ESR1 haplotype metabolic syndrome; LPL and CETP polymorphisms; ESR1 haplotype
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Cahua-Pablo, J.Á.; Cruz, M.; Méndez-Palacios, A.; Antúnez-Ortiz, D.L.; Vences-Velázquez, A.; del Carmen Alarcón-Romero, L.; Parra, E.J.; Tello-Flores, V.A.; Leyva-Vázquez, M.A.; Valladares-Salgado, A.; Pérez-Macedonio, C.P.; Flores-Alfaro, E. Polymorphisms in the LPL and CETP Genes and Haplotype in the ESR1 Gene Are Associated with Metabolic Syndrome in Women from Southwestern Mexico. Int. J. Mol. Sci. 2015, 16, 21539-21554.

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