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Int. J. Mol. Sci. 2015, 16(9), 20873-20895; doi:10.3390/ijms160920873

Two Effective Routes for Removing Lineage Restriction Roadblocks: From Somatic Cells to Hepatocytes

Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, School of Medicine, First Affiliated Hospital, Zhejiang University, Hangzhou 310058, China
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Author to whom correspondence should be addressed.
Academic Editor: Wenbin Deng
Received: 3 August 2015 / Revised: 24 August 2015 / Accepted: 24 August 2015 / Published: 1 September 2015
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Abstract

The conversion of somatic cells to hepatocytes has fundamentally re-shaped traditional concepts regarding the limited resources for hepatocyte therapy. With the various induced pluripotent stem cell (iPSC) generation routes, most somatic cells can be effectively directed to functional stem cells, and this strategy will supply enough pluripotent material to generate promising functional hepatocytes. However, the major challenges and potential applications of reprogrammed hepatocytes remain under investigation. In this review, we provide a summary of two effective routes including direct reprogramming and indirect reprogramming from somatic cells to hepatocytes and the general potential applications of the resulting hepatocytes. Through these approaches, we are striving toward the goal of achieving a robust, mature source of clinically relevant lineages. View Full-Text
Keywords: induced pluripotent stem cells; differentiation; reprogramming; hepatocyte; in vitro; in vivo induced pluripotent stem cells; differentiation; reprogramming; hepatocyte; in vitro; in vivo
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Hu, C.; Li, L. Two Effective Routes for Removing Lineage Restriction Roadblocks: From Somatic Cells to Hepatocytes. Int. J. Mol. Sci. 2015, 16, 20873-20895.

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