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Int. J. Mol. Sci. 2015, 16(8), 18894-18922; doi:10.3390/ijms160818894

Cardiovascular Disease Modeling Using Patient-Specific Induced Pluripotent Stem Cells

1
Department of Cardiovascular Medicine, Saga University, 5-1-1 Nabeshima, Saga 849-8501, Japan
2
Department of Cardiology, Keio University School of Medicine, 35 Shinanomachi Shinjuku-ku, Tokyo 160-8582, Japan
*
Author to whom correspondence should be addressed.
Academic Editor: Wenbin Deng
Received: 29 June 2015 / Revised: 1 August 2015 / Accepted: 3 August 2015 / Published: 12 August 2015
View Full-Text   |   Download PDF [1150 KB, uploaded 12 August 2015]   |  

Abstract

The generation of induced pluripotent stem cells (iPSCs) has opened up a new scientific frontier in medicine. This technology has made it possible to obtain pluripotent stem cells from individuals with genetic disorders. Because iPSCs carry the identical genetic anomalies related to those disorders, iPSCs are an ideal platform for medical research. The pathophysiological cellular phenotypes of genetically heritable heart diseases such as arrhythmias and cardiomyopathies, have been modeled on cell culture dishes using disease-specific iPSC-derived cardiomyocytes. These model systems can potentially provide new insights into disease mechanisms and drug discoveries. This review focuses on recent progress in cardiovascular disease modeling using iPSCs, and discusses problems and future perspectives concerning their use. View Full-Text
Keywords: iPSCs; disease modeling; cardiovascular disease iPSCs; disease modeling; cardiovascular disease
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MDPI and ACS Style

Tanaka, A.; Yuasa, S.; Node, K.; Fukuda, K. Cardiovascular Disease Modeling Using Patient-Specific Induced Pluripotent Stem Cells. Int. J. Mol. Sci. 2015, 16, 18894-18922.

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