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Int. J. Mol. Sci. 2015, 16(9), 20183-20194; doi:10.3390/ijms160920183

Perfluoroalkyl-Functionalized Hyperbranched Polyglycerol as Pore Forming Agents and Supramolecular Hosts in Polymer Microspheres

1
Institute for Chemistry and Biochemistry, Freie Universität Berlin, Takustrasse 3, Berlin 14195, Germany
2
School of Engineering and Applied Sciences, Harvard University, 29 Oxford St., Cambridge, MA 02138, USA
3
Department of Physics, Harvard University, 29 Oxford St., Cambridge, MA 02138, USA
*
Author to whom correspondence should be addressed.
Academic Editor: John Hardy
Received: 30 June 2015 / Revised: 22 July 2015 / Accepted: 17 August 2015 / Published: 26 August 2015
(This article belongs to the Special Issue Supramolecular Interactions)
View Full-Text   |   Download PDF [2494 KB, uploaded 26 August 2015]   |  

Abstract

Perfluoroalkyl-functionalized, hyperbranched polyglycerols that produce stable microbubbles are integrated into a microfluidic emulsion to create porous microspheres. In a previously-presented work a dendrimer with a perfluorinated shell was used. By replacing this dendrimer core with a hyperbranched core and evaluating different core sizes and degrees of fluorinated shell functionalization, we optimized the process to a more convenient synthesis and higher porosities. The new hyperbranched polyglycerol porogens produced more pores and can be used to prepare microspheres with porosity up to 12% (v/v). The presented preparation forms pores with a perfluoroalkyl-functionalized surface that enables the resulting microspheres to act as supramolecular host systems. The microspheres can incorporate gases into the pores and actives in the polymer matrix, while the perfluoroalkylated pore surface can be used to immobilize perfluoro-tagged molecules onto the pores by fluorous-fluorous interaction. View Full-Text
Keywords: polyglycerol; non-covalent; fluorous; supramolecular; microbubbles; microfluidics; porous; template; functional; host-guest system polyglycerol; non-covalent; fluorous; supramolecular; microbubbles; microfluidics; porous; template; functional; host-guest system
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Wagner, O.; Zieringer, M.; Duncanson, W.J.; Weitz, D.A.; Haag, R. Perfluoroalkyl-Functionalized Hyperbranched Polyglycerol as Pore Forming Agents and Supramolecular Hosts in Polymer Microspheres. Int. J. Mol. Sci. 2015, 16, 20183-20194.

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