The Photoprotective Effect of S-Methylmethionine Sulfonium in Skin
AbstractS-Methylmethionine sulfonium (SMMS) was reported to have wound-healing effects; we therefore have investigated the photoprotective effect of SMMS in the present study. SMMS increased the viability of keratinocyte progenitor cells (KPCs) and human dermal fibroblasts (hDFs) following ultraviolet B (UVB) irradiation, and reduced the UVB-induced apoptosis in these cells. SMMS increased the phosphorylation of extracellular signal-regulated kinases (ERK), and the inhibitor of the mitogen-activated protein kinase pathway significantly decreased the SMMS-induced viability of KPCs and hDFs. In addition, SMMS attenuated the UVB-induced reactive oxygen species (ROS) generation in KPCs and hDFs. SMMS induced the collagen synthesis and reduced the matrix metalloproteinase-1 expression in UVB-irradiated hDFs. In animal studies, application of 5% and 10% SMMS before and after UVB-irradiation significantly decreased the UVB-induced erythema index and depletion of Langerhans cells. In summary, SMMS protects KPCs and hDFs from UVB irradiation, and reduces UVB-induced skin erythema and immune suppression. Therefore, SMMS can be used as a cosmetic raw material, and protect skin from UVB. View Full-Text
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Kim, W.-S.; Seo, H.-M.; Kim, W.-K.; Choi, J.-S.; Kim, I.; Sung, J.-H. The Photoprotective Effect of S-Methylmethionine Sulfonium in Skin. Int. J. Mol. Sci. 2015, 16, 17088-17100.
Kim W-S, Seo H-M, Kim W-K, Choi J-S, Kim I, Sung J-H. The Photoprotective Effect of S-Methylmethionine Sulfonium in Skin. International Journal of Molecular Sciences. 2015; 16(8):17088-17100.Chicago/Turabian Style
Kim, Won-Serk; Seo, Hyun-Min; Kim, Wang-Kyun; Choi, Joon-Seok; Kim, Ikyon; Sung, Jong-Hyuk. 2015. "The Photoprotective Effect of S-Methylmethionine Sulfonium in Skin." Int. J. Mol. Sci. 16, no. 8: 17088-17100.