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Int. J. Mol. Sci. 2015, 16(8), 17088-17100; doi:10.3390/ijms160817088

The Photoprotective Effect of S-Methylmethionine Sulfonium in Skin

Department of Dermatology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul 110-746, Korea
College of Pharmacy, Yonsei University, Incheon 406-840, Korea
College of Pharmacy, Catholic University of Daegu, Gyeongbuk 712-702, Korea
Author to whom correspondence should be addressed.
Academic Editor: Terrence Piva
Received: 11 June 2015 / Revised: 14 July 2015 / Accepted: 23 July 2015 / Published: 28 July 2015
(This article belongs to the Section Biochemistry, Molecular and Cellular Biology)
View Full-Text   |   Download PDF [2217 KB, uploaded 28 July 2015]   |  


S-Methylmethionine sulfonium (SMMS) was reported to have wound-healing effects; we therefore have investigated the photoprotective effect of SMMS in the present study. SMMS increased the viability of keratinocyte progenitor cells (KPCs) and human dermal fibroblasts (hDFs) following ultraviolet B (UVB) irradiation, and reduced the UVB-induced apoptosis in these cells. SMMS increased the phosphorylation of extracellular signal-regulated kinases (ERK), and the inhibitor of the mitogen-activated protein kinase pathway significantly decreased the SMMS-induced viability of KPCs and hDFs. In addition, SMMS attenuated the UVB-induced reactive oxygen species (ROS) generation in KPCs and hDFs. SMMS induced the collagen synthesis and reduced the matrix metalloproteinase-1 expression in UVB-irradiated hDFs. In animal studies, application of 5% and 10% SMMS before and after UVB-irradiation significantly decreased the UVB-induced erythema index and depletion of Langerhans cells. In summary, SMMS protects KPCs and hDFs from UVB irradiation, and reduces UVB-induced skin erythema and immune suppression. Therefore, SMMS can be used as a cosmetic raw material, and protect skin from UVB. View Full-Text
Keywords: S-methylmethionine sulfonium; UVB protection; dermal fibroblasts; keratinocyte progenitor cells; erythema S-methylmethionine sulfonium; UVB protection; dermal fibroblasts; keratinocyte progenitor cells; erythema

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Kim, W.-S.; Seo, H.-M.; Kim, W.-K.; Choi, J.-S.; Kim, I.; Sung, J.-H. The Photoprotective Effect of S-Methylmethionine Sulfonium in Skin. Int. J. Mol. Sci. 2015, 16, 17088-17100.

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