Next Article in Journal
Sequencing Overview of Ewing Sarcoma: A Journey across Genomic, Epigenomic and Transcriptomic Landscapes
Next Article in Special Issue
Treatment Strategies that Enhance the Efficacy and Selectivity of Mitochondria-Targeted Anticancer Agents
Previous Article in Journal
Deregulated SLC2A1 Promotes Tumor Cell Proliferation and Metastasis in Gastric Cancer
Previous Article in Special Issue
Mevalonate Pathway Blockade, Mitochondrial Dysfunction and Autophagy: A Possible Link
Article Menu
Issue 7 (July) cover image

Export Article

Open AccessReview
Int. J. Mol. Sci. 2015, 16(7), 16158-16175; doi:10.3390/ijms160716158

Thyroid Hormone Mediated Modulation of Energy Expenditure

Division of Endocrinology and Metabolism, Department of Internal Medicine, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA
*
Author to whom correspondence should be addressed.
Academic Editors: Jaime M. Ross and Giuseppe Coppotelli
Received: 24 June 2015 / Revised: 7 July 2015 / Accepted: 9 July 2015 / Published: 16 July 2015
(This article belongs to the Special Issue Mitochondrial Dysfunction in Ageing and Diseases)
View Full-Text   |   Download PDF [934 KB, uploaded 16 July 2015]   |  

Abstract

Thyroid hormone (TH) has diverse effects on mitochondria and energy expenditure (EE), generating great interest and research effort into understanding and harnessing these actions for the amelioration and treatment of metabolic disorders, such as obesity and diabetes. Direct effects on ATP utilization are a result of TH’s actions on metabolic cycles and increased cell membrane ion permeability. However, the majority of TH induced EE is thought to be a result of indirect effects, which, in turn, increase capacity for EE. This review discusses the direct actions of TH on EE, and places special emphasis on the indirect actions of TH, which include mitochondrial biogenesis and reduced metabolic efficiency through mitochondrial uncoupling mechanisms. TH analogs and the metabolic actions of T2 are also discussed in the context of targeted modulation of EE. Finally, clinical correlates of TH actions on metabolism are briefly presented. View Full-Text
Keywords: thyroid hormone; mitochondria; uncoupling mechanisms; mitochondrial biogenesis; metabolism; energy expenditure; thyroid hormone receptors thyroid hormone; mitochondria; uncoupling mechanisms; mitochondrial biogenesis; metabolism; energy expenditure; thyroid hormone receptors
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Vaitkus, J.A.; Farrar, J.S.; Celi, F.S. Thyroid Hormone Mediated Modulation of Energy Expenditure. Int. J. Mol. Sci. 2015, 16, 16158-16175.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top