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Int. J. Mol. Sci. 2015, 16(7), 15776-15784; doi:10.3390/ijms160715776

Hypothyroidism Exacerbates Thrombophilia in Female Rats Fed with a High Fat Diet

1
Clinical Institute for Medical and Chemical Laboratory Diagnostics, Medical University Graz, 8036 Graz, Austria
2
Department of Pathology, Medical University of Graz, 8036 Graz, Austria
3
Division of Endocrinology and Metabolism, Medical University Graz, 8036 Graz, Austria
4
Physiological Chemistry, Medical University of Graz, 8036 Graz, Austria
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editor: Toshiro Arai
Received: 29 June 2015 / Revised: 29 June 2015 / Accepted: 8 July 2015 / Published: 10 July 2015
(This article belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
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Abstract

Clotting abnormalities are discussed both in the context with thyroid dysfunctions and obesity caused by a high fat diet. This study aimed to investigate the impact of hypo-, or hyperthyroidism on the endogenous thrombin potential (ETP), a master indicator of clotting activation, on Sprague Dawley rats fed a normal or high fat diet. Female Sprague Dawley rats (n = 66) were grouped into normal diet (ND; n = 30) and high-fat diet (HFD; n = 36) groups and subdivided into controls, hypothyroid and hyperthyroid groups, induced through propylthiouracil or triiodothyronine (T3) treatment, respectively. After 12 weeks of treatment ETP, body weight and food intake were analyzed. Successfully induced thyroid dysfunction was shown by T3 levels, both under normal and high fat diet. Thyroid dysfunction was accompanied by changes in calorie intake and body weight. In detail, compared to euthyroid controls, hypothyroid rats showed significantly increased—and hyperthyroid animals significantly decreased—ETP levels. High fat diet potentiated these effects in both directions. In summary, we are the first to show that hypothyroidism and high fat diet potentiate the thrombotic capacity of the clotting system in Sprague Dawley rats. This effect may be relevant for cardiovascular disease where thyroid function is poorly understood as a pathological contributor in the context of clotting activity and obesogenic nutrition. View Full-Text
Keywords: endogenous thrombin potential (ETP); hyperthyroidism; hypothyroidism; fat feeding; Sprague Dawley rats endogenous thrombin potential (ETP); hyperthyroidism; hypothyroidism; fat feeding; Sprague Dawley rats
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Mangge, H.; Prüller, F.; Zelzer, S.; Ainödhofer, H.; Pailer, S.; Kieslinger, P.; Haybaeck, J.; Obermayer-Pietsch, B.; Cvirn, G.; Gruber, H.-J. Hypothyroidism Exacerbates Thrombophilia in Female Rats Fed with a High Fat Diet. Int. J. Mol. Sci. 2015, 16, 15776-15784.

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