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Int. J. Mol. Sci. 2015, 16(6), 13217-13258; doi:10.3390/ijms160613217

Broader Autism Phenotype in Siblings of Children with ASD—A Review

Faculty of Psychology, University of Warsaw, Stawki 5/7, 00-183 Warsaw, Poland
These authors contributed equally to this work.
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Author to whom correspondence should be addressed.
Academic Editor: Merlin G. Butler
Received: 18 January 2015 / Revised: 21 April 2015 / Accepted: 19 May 2015 / Published: 10 June 2015
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Abstract

Although less pronounced, social, cognitive, and personality characteristics associated with autism spectrum disorders (ASD) may be present in people who do not meet ASD diagnostic criteria, especially in first-degree relatives of individuals with ASD. Research on these characteristics, referred to as broader autism phenotype (BAP), provides valuable data on potential expressions of autism-specific deficits in the context of family relations. This paper offers a review of research on BAP in siblings of individuals with ASD, focusing on reports regarding social, communication, and cognitive deficits, published from 1993 to 2014. The studies are divided into two groups based on participants’ age: papers on preschool and older siblings of individuals with ASD; and publications on infants at risk for ASD. On the basis of this review, suggestions are offered for further research and its significance for our understanding of the genetic determinants of autism. View Full-Text
Keywords: broad autism phenotype; siblings; review; at-risk infants broad autism phenotype; siblings; review; at-risk infants
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Pisula, E.; Ziegart-Sadowska, K. Broader Autism Phenotype in Siblings of Children with ASD—A Review. Int. J. Mol. Sci. 2015, 16, 13217-13258.

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